Ibragimov R Sh, Kerimova N K, Ragimov R G
Fiziol Zh SSSR Im I M Sechenova. 1989 Oct;75(10):1355-60.
Changes in the serotonin and 5-oxyindolacetic acid contents in mitochondrial fractions of different brain structures were studied prior to and after oxytocin intraventricular microinjection in normal and drug-dependent rats. The oxytocin administration exerted different effects on serotonin metabolism in different brain structures. The drug-dependent animals showed a higher level of the brain serotonin as compared to the control. The oxytocin administration decreased hypothalamic and hippocampal serotonin levels. The oxytocin effect on the processes of drug dependence is discussed.
在正常大鼠和药物依赖大鼠脑室内微量注射催产素前后，研究了不同脑结构线粒体组分中血清素和5-羟吲哚乙酸含量的变化。催产素给药对不同脑结构中的血清素代谢产生了不同影响。与对照组相比，药物依赖动物的脑血清素水平更高。催产素给药降低了下丘脑和海马体中的血清素水平。文中讨论了催产素对药物依赖过程的影响。
