Veri Kadi, Uibo Oivi, Talvik Inga, Talvik Tiina
Department of Pediatrics, University of Tartu, Lunini 6, 51014 Tartu, Estonia.
Medicina (Kaunas). 2013;49(11):487-9.
Drug-induced acute pancreatitis is a rare condition in childhood, and information about the incidence of valproic acid-induced acute pancreatitis in the pediatric population is scarce. In this clinical case, we report a first documented pediatric case of valproic acid-induced pancreatitis in Estonia. A 15-year-old boy with juvenile myoclonic epilepsy developed acute pancreatitis after 2-month therapy with valproic acid. The symptoms of pancreatitis subsided within 1 week after the discontinuation of treatment with valproic acid. Acute pancreatitis should be suspected in any pediatric patient with gastrointestinal symptoms during valproate treatment.
药物性急性胰腺炎在儿童中是一种罕见病症，关于丙戊酸诱导的急性胰腺炎在儿科人群中的发病率信息匮乏。在本临床病例中，我们报告了爱沙尼亚首例有记录的丙戊酸诱导胰腺炎的儿科病例。一名患有青少年肌阵挛性癫痫的15岁男孩在接受丙戊酸治疗2个月后发生急性胰腺炎。在停用丙戊酸治疗后1周内，胰腺炎症状消退。在任何接受丙戊酸盐治疗期间出现胃肠道症状的儿科患者中，均应怀疑有急性胰腺炎。
