Köhler Norbert, Gansera Lutz, Holze Sigrun, Friedrich Michael, Rebmann Udo, Stolzenburg Jens-Uwe, Truss Michael C, Fahlenkamp Dirk, Scholz Hans-Jörg, Brähler Elmar
Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany,
Support Care Cancer. 2014 Nov;22(11):2883-9. doi: 10.1007/s00520-014-2265-5. Epub 2014 May 14.
A multi-centre, longitudinal study was conducted to assess the prevalence of fatigue amongst men with localized prostate cancer, to describe several dimensions of fatigue and to explore the predictability of fatigue by psychological distress and physical function.
The prevalence of fatigue was evaluated using the Multidimensional Fatigue Inventory in 329 prostate cancer patients before, 3, 6 and 12 months after surgery. Psychological distress was assessed using the Hospital Anxiety and Depression Scale. Physical function was measured using the EORTC QLQ-C30.
After surgery, about 14 % of the patients were screened with chronic fatigue. For all dimensions of fatigue, only small longitudinal changes could be observed. Psychological distress could be identified as a good predictor of fatigue after but not before surgery.
Radical prostatectomy has no or little impact on the prevalence of fatigue. However, about 14 % of patients with chronic fatigue could possibly benefit from psychosomatic interventions. Interventions should consider the simultaneous appearance of fatigue and psychological distress and a reduced physical function.
开展一项多中心纵向研究，以评估局限性前列腺癌男性患者疲劳的患病率，描述疲劳的几个维度，并探讨心理困扰和身体功能对疲劳的预测能力。
在329例前列腺癌患者手术前、术后3个月、6个月和12个月，使用多维疲劳量表评估疲劳的患病率。使用医院焦虑抑郁量表评估心理困扰。使用欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ-C30）测量身体功能。
术后约14%的患者被筛查出患有慢性疲劳。对于疲劳的所有维度，只能观察到微小的纵向变化。心理困扰可被确定为术后而非术前疲劳的良好预测指标。
根治性前列腺切除术对疲劳患病率没有或几乎没有影响。然而，约14%的慢性疲劳患者可能受益于心身干预。干预应考虑疲劳与心理困扰的同时出现以及身体功能下降的情况。
