Department of Clinical Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Prostate Cancer Prostatic Dis. 2010 Jun;13(2):144-50. doi: 10.1038/pcan.2009.61. Epub 2010 Jan 26.
Chronic fatigue (CF) is a distressing symptom that follows cancer treatment; however, it has rarely been studied in hormone-naïve prostate cancer survivors after radical prostatectomy (RP) or definitive radiotherapy (RAD). We investigated CF in prostate cancer survivors after RP or RAD as monotherapy and explored associations between CF and medical and psychosocial variables. A population-based, cross-sectional postal survey in 2006 included Norwegian hormone-naïve survivors with the diagnosis of prostate cancer in 2004 who were treated with RP (n=337) or RAD (n=184). The primary outcome variable was prevalence of CF (defined as fatigue lasting 6 months or longer). Twelve to 32 months after RP and RAD, 13.4 and 26.1% of the patients after, respectively, RP and RAD reported CF inversely associated with pretreatment age (P=0.003). In multivariate analysis, high neuroticism, post-treatment co-morbidity, pain, urinary and intestinal dysfunction, but not sexual dysfunction, were positively associated with reporting CF. Further studies of CF in prostate cancer survivors should take into consideration the survivors' pretreatment medical and psychosocial situation.
慢性疲劳（CF）是癌症治疗后出现的一种令人痛苦的症状；然而，对于接受根治性前列腺切除术（RP）或根治性放疗（RAD）后的激素初治前列腺癌幸存者，这种情况很少被研究。我们调查了 RP 或 RAD 单一治疗后前列腺癌幸存者的 CF，并探讨了 CF 与医学和社会心理变量之间的关系。2006 年进行了一项基于人群的横断面邮寄调查，包括 2004 年诊断为前列腺癌且接受 RP（n=337）或 RAD（n=184）治疗的挪威激素初治幸存者。主要结局变量为 CF 的患病率（定义为持续 6 个月或更长时间的疲劳）。RP 和 RAD 治疗后 12-32 个月，分别有 13.4%和 26.1%的 RP 和 RAD 治疗后患者报告 CF，与治疗前年龄呈负相关（P=0.003）。多变量分析显示，高神经质、治疗后合并症、疼痛、尿和肠功能障碍，但无性功能障碍，与报告 CF 呈正相关。进一步研究前列腺癌幸存者的 CF 时，应考虑幸存者治疗前的医学和社会心理状况。
