Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Diabetes. 2015 Jan;7(1):31-40. doi: 10.1111/1753-0407.12166. Epub 2014 Jul 15.
Adiponectin gene polymorphisms have been reported to be associated with the risk of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. However, the results are inconsistent.
Electronic literature databases and reference lists of relevant articles published until December 2013 were searched as part of a systematic review and meta-analysis to clarify the association between adiponectin gene polymorphisms and DN susceptibility in T2DM. Fixed- or random-effects models were used to calculate the effect sizes of odds ratio (OR) and 95% confidence intervals (95% CI).
Eleven case control studies were included. Overall, a significant association was observed for rs2241766T/G polymorphisms under the recessive model (GG vs. TT+TG: OR 1.75; 95% CI 1.09-2.80; P = 0.02). For rs17300539G/A, a significant association was observed under the GA vs. GG model (OR 1.74; 95% CI 1.13-2.68; P = 0.01) and A vs. G allele model OR 1.65; 95% CI 1.13-2.41; P = 0.009). After stratification by ethnicity, we found that the rs2241766 T/G dominant model (GG+TG vs. TT: OR 1.52; 95% CI 1.12-2.07; P = 0.007), heterozygous model (TG vs. TT: OR 1.52; 95% CI 1.01-2.27; P = 0.04) and G vs. T allele (OR 1.50; 95% CI 1.07-2.10; P = 0.02) may be associated with DN risk in the Caucasian population. For rs17300593G/A, the dominant model (GA+AA vs. GG: OR 1.75; 95% CI 1.15-2.67; P = 0.009) may be associated with DN risk in the Caucasian population.
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
脂肪细胞因子基因多态性与 2 型糖尿病患者糖尿病肾病（DN）的风险相关。然而，结果并不一致。
系统评价和荟萃分析中检索了截至 2013 年 12 月发表的相关文章的电子文献数据库和参考文献列表，以阐明脂肪细胞因子基因多态性与 2 型糖尿病患者 DN 易感性之间的关系。采用固定效应或随机效应模型计算比值比（OR）和 95%置信区间（95%CI）的效应大小。
共纳入 11 项病例对照研究。总体而言，在隐性模型下，rs2241766T/G 多态性存在显著相关性（GG 比 TT+TG：OR 1.75；95%CI 1.09-2.80；P=0.02）。对于 rs17300539G/A，在 GA 比 GG 模型（OR 1.74；95%CI 1.13-2.68；P=0.01）和 A 比 G 等位基因模型（OR 1.65；95%CI 1.13-2.41；P=0.009）下存在显著相关性。按种族分层后，我们发现 rs2241766T/G 显性模型（GG+TG 比 TT：OR 1.52；95%CI 1.12-2.07；P=0.007）、杂合模型（TG 比 TT：OR 1.52；95%CI 1.01-2.27；P=0.04）和 G 比 T 等位基因（OR 1.50；95%CI 1.07-2.10；P=0.02）可能与高加索人群的 DN 风险相关。对于 rs17300593G/A，显性模型（GA+AA 比 GG：OR 1.75；95%CI 1.15-2.67；P=0.009）可能与高加索人群的 DN 风险相关。
脂肪细胞因子 rs2241766T/G 和 rs17300593G/A 而不是 rs1501299G/T 和 rs266729C/G 多态性与 2 型糖尿病患者的 DN 风险相关，特别是在高加索人群中。
