School of Medicine, Nankai University, Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, China.
Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Nephrology Institute of Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, China.
J Diabetes Res. 2020 Jun 28;2020:5158497. doi: 10.1155/2020/5158497. eCollection 2020.
BACKGROUND: This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the gene in the occurrence of diabetic kidney disease (DKD). METHODS: Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models. Interstudy heterogeneity was examined using the Q test and statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates. Begg's funnel plot and Egger's test were applied to inspect potential publication bias among the included studies. RESULTS: The overall ORs reflected a positive correlation between the rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR = 1.51, 95%CI = 1.16 - 1.95; OR = 1.43, 95%CI = 1.11 - 1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup. CONCLUSION: The rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients.
背景：本荟萃分析旨在更全面地评估基因中单核苷酸多态性（SNP）rs2241766 在糖尿病肾病（DKD）发生中的作用。
方法：从 Embase、PubMed、Medline、Cochrane 图书馆、Google Scholar、万方和中国国家知识基础设施（CNKI）等数字数据库中确定相关研究。采用固定或随机效应模型汇总比值比（OR）及其相应的 95%置信区间（95%CI）。采用 Q 检验和 I 2 统计量检验研究间异质性，并进行敏感性分析以检验总体估计值的统计稳定性。采用 Begg 漏斗图和 Egger 检验检验纳入研究中的潜在发表偏倚。
结果：总体 ORs 反映了 rs2241766 多态性与 GG 与 TT 及 GG 与 TT+TG 比较中 DKD 易感性之间的正相关（OR=1.51，95%CI=1.16-1.95；OR=1.43，95%CI=1.11-1.85）。按种族和疾病类型进行分层分析后，在白人和非裔亚组以及 2 型糖尿病亚组中也显示出类似的趋势。
结论：rs2241766 多态性可能与 DKD 风险增加相关，尤其是在白人和非裔人群以及 2 型糖尿病患者中。
J Diabetes Res. 2020
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