Kavitha B T, Shruthi S D, Rai S Padmalatha, Ramachandra Y L
P.G. Department of Studies and Research in Biotechnology and Bioinformatics, Kuvempu University, Shankaraghatta - 577 451, Karnataka, India.
P.G. Department of Studies and Research in Biotechnology and Bioinformatics, Kuvempu University, Shankaraghatta - 577 451, Karnataka, India ; Department of Biotechnology, The Oxford College of Science, Bangalore - 560 102, India.
J Basic Clin Pharm. 2011 Jun;2(3):139-42. Epub 2011 Aug 15.
The present study was conducted to evaluate the hepatoprotective activity of different extracts of Tinospora cordifolia against carbon tetrachloride (CCl4) induced liver damage in rats. The pet ether, ethanol and aqueous extracts of various parts of the plant such as leaf, stem and root were tested at the dose of 200mg/kg body weight orally using Wistar albino rats and Silymarin was given as reference standard. Ethanolic extract of all the parts showed significant hepatoprotective effect by reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected model which is followed by aqueous and pet ether extracts. The chemical constituents reported from the plant belong to different classes such as alkaloids, flavanoids, glycosides, steroids, terpenoids, phenolics and saponins. The overall experimental results suggests that the biologically active phytoconstituents such as flavonoids, alkaloids present in the ethanolic extract of plant Tinospora cordifolia, may be responsible for the significant hepatoprotective activity. Therefore, results justify the use of Tinospora cordifolia as a hepatoprotective agent.
本研究旨在评估匙叶翼首草不同提取物对四氯化碳（CCl4）诱导的大鼠肝损伤的保肝活性。使用Wistar白化大鼠，以200mg/kg体重的剂量口服给予该植物叶、茎和根等不同部位的石油醚、乙醇和水提取物，并以水飞蓟宾作为参考标准。在所选模型中，所有部位的乙醇提取物通过降低血清酶丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）和总胆红素（TBL）显示出显著的保肝作用，其次是水提取物和石油醚提取物。从该植物中报道的化学成分属于不同类别，如生物碱、黄酮类、糖苷、甾体、萜类、酚类和皂苷。总体实验结果表明，匙叶翼首草乙醇提取物中存在的生物活性植物成分如黄酮类、生物碱可能是其显著保肝活性的原因。因此，结果证明匙叶翼首草可作为一种保肝剂使用。
