El Houari T, Haddiya I, El Ouafi N, Bazid Z
Department of Cardiology, Faculty of Medicine, University Mohamed First, Oujda, Morocco.
Department of Nephrology, Faculty of Medicine, University Mohamed First, Oujda, Morocco.
Case Rep Cardiol. 2013;2013:842606. doi: 10.1155/2013/842606. Epub 2013 Apr 3.
Calcium channel blockers (CCBs) are prescribed in a wide variety of cardiovascular conditions. Nevertheless, they remain a major cause of cardiovascular drug overdose that often leads to a lethal outcome. We report the case of an intoxication with amlodipine, which caused severe hypotension, in a young woman. The patient was initially treated with fluids, calcium gluconate, and Dobutamine without effect. She then received hyperinsulinemia euglycemia therapy. A rise in blood pressure (BP) was observed two hours after insulin was started. The next day, the insulin infusion was stopped and seven days later the patient was discharged from the hospital after psychiatric consultation. The positive inotropic effect of insulin therapy in our patient supports previous findings that suggest its use as a first-line therapy in the management of CCBs overdose.
钙通道阻滞剂（CCBs）被广泛用于治疗各种心血管疾病。然而，它们仍然是心血管药物过量的主要原因，常常导致致命后果。我们报告了一名年轻女性因氨氯地平中毒导致严重低血压的病例。患者最初接受了补液、葡萄糖酸钙和多巴酚丁胺治疗，但无效。随后她接受了高胰岛素正常血糖疗法。开始使用胰岛素两小时后观察到血压升高。第二天，停止胰岛素输注，七天后患者经精神科会诊后出院。胰岛素疗法对我们患者的正性肌力作用支持了先前的研究结果，即建议将其用作治疗CCBs过量的一线疗法。
