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一次不够:氨氯地平(钙通道阻滞剂)与氯硝西泮(苯二氮䓬类药物)同时中毒的病例报告

Once was not enough: A case report of the concomitant intoxication of amlodipine (calcium channel blocker) and clonazepam (benzodiazepine).

作者信息

Gautam Swotantra, Chamlagain Mandita, Yadav Gopal Kumar, Acharya Santosh

机构信息

Department of Critical Care Medicine Nidan Hospital Lalitpur Nepal.

Department of Emergency Medicine Kakani Primary Health Care Centre Nuwakot Nepal.

出版信息

Clin Case Rep. 2022 Jul 11;10(7):e6042. doi: 10.1002/ccr3.6042. eCollection 2022 Jul.

Abstract

We report a case of concurrent ingestion of Clonazepam and Amlodipine in a 25-year-old man, in a second attempt to take his life, which resulted in unconsciousness, hypotension, and hypokalemia. The clinical and/or biochemical presentation varied from the individual pattern when ingested. In the scarcity of consensus recommendations, supportive treatment helped.

摘要

我们报告了一例25岁男性同时服用氯硝西泮和氨氯地平的病例,这是他第二次自杀未遂,结果导致昏迷、低血压和低钾血症。临床和/或生化表现与单独摄入时的个体模式有所不同。在缺乏共识性建议的情况下,支持性治疗起到了帮助作用。

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本文引用的文献

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Flumazenil in benzodiazepine overdose.氟马西尼用于苯二氮䓬类药物过量中毒
CMAJ. 2016 Dec 6;188(17-18):E537. doi: 10.1503/cmaj.160357. Epub 2016 Nov 14.
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Flumazenil, naloxone and the 'coma cocktail'.氟马西尼、纳洛酮与“昏迷合剂”
Br J Clin Pharmacol. 2016 Mar;81(3):428-36. doi: 10.1111/bcp.12731. Epub 2015 Sep 21.
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A survival case in a severe amlodipine intoxication.一例严重氨氯地平中毒的存活病例。
Case Rep Cardiol. 2013;2013:842606. doi: 10.1155/2013/842606. Epub 2013 Apr 3.

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