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一次不够：氨氯地平（钙通道阻滞剂）与氯硝西泮（苯二氮䓬类药物）同时中毒的病例报告

Once was not enough: A case report of the concomitant intoxication of amlodipine (calcium channel blocker) and clonazepam (benzodiazepine).

作者信息

Gautam Swotantra, Chamlagain Mandita, Yadav Gopal Kumar, Acharya Santosh

机构信息

Department of Critical Care Medicine Nidan Hospital Lalitpur Nepal.

Department of Emergency Medicine Kakani Primary Health Care Centre Nuwakot Nepal.

出版信息

Clin Case Rep. 2022 Jul 11;10(7):e6042. doi: 10.1002/ccr3.6042. eCollection 2022 Jul.

DOI:10.1002/ccr3.6042
PMID:35846941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9272439/
Abstract

We report a case of concurrent ingestion of Clonazepam and Amlodipine in a 25-year-old man, in a second attempt to take his life, which resulted in unconsciousness, hypotension, and hypokalemia. The clinical and/or biochemical presentation varied from the individual pattern when ingested. In the scarcity of consensus recommendations, supportive treatment helped.

摘要

我们报告了一例25岁男性同时服用氯硝西泮和氨氯地平的病例，这是他第二次自杀未遂，结果导致昏迷、低血压和低钾血症。临床和/或生化表现与单独摄入时的个体模式有所不同。在缺乏共识性建议的情况下，支持性治疗起到了帮助作用。

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Clin Case Rep. 2022 Jul 11;10(7):e6042. doi: 10.1002/ccr3.6042. eCollection 2022 Jul.
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本文引用的文献

1
Occurrence of hypoglycemia in patients with benzodiazepines poisoning: A cross-sectional study.苯二氮䓬类药物中毒患者低血糖的发生情况：一项横断面研究。
Ann Med Surg (Lond). 2021 Sep 3;69:102772. doi: 10.1016/j.amsu.2021.102772. eCollection 2021 Sep.
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Quantification of respiratory depression during pre-operative administration of midazolam using a non-invasive respiratory volume monitor.使用无创呼吸容积监测仪对咪达唑仑术前给药期间的呼吸抑制进行量化。
PLoS One. 2017 Feb 24;12(2):e0172750. doi: 10.1371/journal.pone.0172750. eCollection 2017.
3
Flumazenil in benzodiazepine overdose.氟马西尼用于苯二氮䓬类药物过量中毒
CMAJ. 2016 Dec 6;188(17-18):E537. doi: 10.1503/cmaj.160357. Epub 2016 Nov 14.
4
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults.成人钙通道阻滞剂中毒管理的专家共识建议
Crit Care Med. 2017 Mar;45(3):e306-e315. doi: 10.1097/CCM.0000000000002087.
5
Flumazenil, naloxone and the 'coma cocktail'.氟马西尼、纳洛酮与“昏迷合剂”
Br J Clin Pharmacol. 2016 Mar;81(3):428-36. doi: 10.1111/bcp.12731. Epub 2015 Sep 21.
6
Noncardiogenic Pulmonary Edema after Amlodipine Overdose without Refractory Hypotension and Bradycardia.氨氯地平过量后出现非心源性肺水肿，无顽固性低血压和心动过缓。
Case Rep Emerg Med. 2015;2015:546012. doi: 10.1155/2015/546012. Epub 2015 May 5.
7
Management of calcium channel antagonist overdose with hyperinsulinemia-euglycemia therapy: case series and review of the literature.高胰岛素-正常血糖疗法治疗钙通道拮抗剂过量：病例系列及文献综述
Case Rep Crit Care. 2012;2012:927040. doi: 10.1155/2012/927040. Epub 2012 Feb 14.
8
A survival case in a severe amlodipine intoxication.一例严重氨氯地平中毒的存活病例。
Case Rep Cardiol. 2013;2013:842606. doi: 10.1155/2013/842606. Epub 2013 Apr 3.
9
Amlodipine poisioning complicated with acute non-cardiogenic pulmonary oedema.氨氯地平中毒并发急性非心源性肺水肿。
BMJ Case Rep. 2011 Sep 4;2011:bcr0720114467. doi: 10.1136/bcr.07.2011.4467.
10
Successful treatment of refractory hypotension, noncardiogenic pulmonary edema and acute kidney injury after an overdose of amlodipine.氨氯地平过量服用后难治性低血压、非心源性肺水肿和急性肾损伤的成功治疗。
Indian J Crit Care Med. 2011 Jul;15(3):182-4. doi: 10.4103/0972-5229.84901.