因滥用诺氟沙星复合制剂导致的低钾血症和肾小管性酸中毒
Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus.
作者信息
Blackstock M J, Lee A
机构信息
Critical Care, Anaesthesia and Pain Management Department, Royal Infirmary of Edinburgh 51 Little France Crescent, Edinburgh EH16 4SA, UK.
出版信息
Case Rep Crit Care. 2012;2012:141505. doi: 10.1155/2012/141505. Epub 2012 Aug 29.
Abstract
Nurofen Plus is a common analgesic containing ibuprofen and codeine. We present a case of a 38-year-old lady who developed renal tubular acidosis with severe hypokalaemia, after chronic abuse of Nurofen Plus tablets. She presented with confusion and profound biochemical abnormalities requiring critical care admission for electrolyte replacement. Ibuprofen causes renal tubular acidosis due to its effects on carbonic anhydrase activity.
摘要
诺洛芬加强版是一种含有布洛芬和可待因的常见镇痛药。我们报告一例38岁女性病例，该患者在长期滥用诺洛芬加强版片剂后出现肾小管酸中毒并伴有严重低钾血症。她表现为意识模糊和严重的生化异常，需要入住重症监护病房进行电解质补充。布洛芬因其对碳酸酐酶活性的影响而导致肾小管酸中毒。
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本文引用的文献
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Med J Aust. 2011 Mar 21;194(6):313-6. doi: 10.5694/j.1326-5377.2011.tb02982.x.
2
Profound hypokalaemia due to Nurofen Plus and Red Bull misuse.因滥用奈普生片和红牛导致严重低钾血症。
Crit Care Resusc. 2010 Jun;12(2):109-10.
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Polyuria, acidosis, and coma following massive ibuprofen ingestion.大剂量布洛芬摄入后出现多尿、酸中毒和昏迷。
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The role of carbonic anhydrases in renal physiology.碳酸酐酶在肾脏生理学中的作用。
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Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.对乙酰氨基酚所致急性肝衰竭：一项美国多中心前瞻性研究的结果
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10
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