Wang F R
Hebei Medical College, Shijiazhuang.
Zhonghua Zhong Liu Za Zhi. 1989 Sep;11(5):326-8.
The effect of pinyangmycin (PYM) on the growth and differentiation of the transplantable squamous cell carcinoma of forestomach (GS-742) in mice was studied by optical and electron microscope. The results showed that PYM had marked growth inhibitory effect on GS-742. Histopathologically, tumor necrosis, fibrosis and infiltration of lymphocytes were obvious in mice treated with PYM. A decrease in mitosis and increase in keratinization were also conspicuous. Ultrastructurally, microvilli on tumor cells were significantly reduced in number with formation of blebs and ruffles; mitochondria were swollen; endoplasmic reticulum was often decreased and dilated; and desmosome and tonofibrils were increased. The results indicate that PYM exerts its growth-inhibitory effect on tumor cells by cell damage, inhibition of mitosis and promotion of differentiation.
采用光学显微镜和电子显微镜研究了平阳霉素（PYM）对小鼠移植性前胃癌（GS-742）生长和分化的影响。结果显示，PYM对GS-742有显著的生长抑制作用。组织病理学上，经PYM处理的小鼠肿瘤坏死、纤维化及淋巴细胞浸润明显。有丝分裂减少和角化增加也很显著。超微结构上，肿瘤细胞微绒毛数量显著减少，出现泡状和褶边结构；线粒体肿胀；内质网常减少且扩张；桥粒和张力原纤维增加。结果表明，PYM通过细胞损伤、抑制有丝分裂和促进分化对肿瘤细胞发挥生长抑制作用。
