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非甾体抗炎药对非黑色素瘤皮肤癌无化学预防作用：来自荟萃分析的证据。

No chemopreventive effect of nonsteroidal anti-inflammatory drugs on nonmelanoma skin cancer: evidence from meta-analysis.

作者信息

Zhang Bo, Liang Xiaolu, Ye Liaosha, Wang Yungui

机构信息

Training Division, Third Military Medical Universality, Chongqing, China; Department of medical administration, General Hospital of Beijing Military Command, Beijing, China.

Department of Ultrasonography, General Hospital of Beijing Military Command, Beijing, China.

出版信息

PLoS One. 2014 May 14;9(5):e96887. doi: 10.1371/journal.pone.0096887. eCollection 2014.

DOI:10.1371/journal.pone.0096887
PMID:24828489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4020781/
Abstract

BACKGROUND

Nonmelanoma skin cancer (NMSC),which includes squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is the most common form of cancer, and its incidence is increasing. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to be chemopreventive for NMSC. However, the results from published studies were controversial.

METHODS

We searched the PubMed and Embase databases for relevant studies. Moreover, relevant reviews regarding the use of NSAIDs for NMSC patients were examined for potential inclusive studies. To measure the effects of NSAIDs, the relative risk (RR) was analyzed.

RESULTS

A Total of 8 studies were included in our meta-analysis. We found that NSAIDs use was not associated with a reduced risk of SCC or BCC under the random effects model (pooled RR  =  0.86, 95% CI, 0.73-1.02, P  =  0.085; pooled RR  =  0.94, 95% CI 0.85-1.04, P  =  0.266; respectively).

CONCLUSION

From the included studies, we found no statistically significant chemopreventive effect on NMSC of NSAIDs. This finding warrants more prospective studies evaluating the relationship between NSAIDs and NMSC.

摘要

背景

非黑色素瘤皮肤癌（NMSC）包括鳞状细胞癌（SCC）和基底细胞癌（BCC），是最常见的癌症形式，其发病率正在上升。据报道，非甾体抗炎药（NSAIDs）对NMSC具有化学预防作用。然而，已发表研究的结果存在争议。

方法

我们在PubMed和Embase数据库中检索了相关研究。此外，还查阅了有关NSAIDs用于NMSC患者的相关综述，以寻找可能纳入的研究。为了衡量NSAIDs的效果，我们分析了相对风险（RR）。

结果

我们的荟萃分析共纳入了8项研究。我们发现，在随机效应模型下，使用NSAIDs与SCC或BCC风险降低无关（合并RR = 0.86，95%CI为0.73 - 1.02，P = 0.085；合并RR = 0.94，95%CI为0.85 - 1.04，P = 0.266）。

结论

从纳入的研究中，我们发现NSAIDs对NMSC没有统计学上显著的化学预防作用。这一发现需要更多前瞻性研究来评估NSAIDs与NMSC之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/6dc63c715362/pone.0096887.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/3b878a769cc3/pone.0096887.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/dd33792b7a1b/pone.0096887.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/c33122c31d9d/pone.0096887.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/0b51ed743625/pone.0096887.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/6dc63c715362/pone.0096887.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/3b878a769cc3/pone.0096887.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/dd33792b7a1b/pone.0096887.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/c33122c31d9d/pone.0096887.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/0b51ed743625/pone.0096887.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5726/4020781/6dc63c715362/pone.0096887.g005.jpg

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本文引用的文献

1
Occupational skin cancer induced by ultraviolet radiation and its prevention.职业性皮肤癌由紫外线辐射引起及其预防。
Br J Dermatol. 2012 Aug;167 Suppl 2:76-84. doi: 10.1111/j.1365-2133.2012.11090.x.
2
Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study.非甾体抗炎药、对乙酰氨基酚与护士健康研究中的皮肤癌风险。
Cancer Causes Control. 2012 Sep;23(9):1451-61. doi: 10.1007/s10552-012-0019-6. Epub 2012 Jul 5.
3
Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: a population-based case-control study.
Cancers (Basel). 2022 Jul 27;14(15):3653. doi: 10.3390/cancers14153653.
4
COX-2 inhibitors show no preventive effect in the development of skin cancer.COX-2 抑制剂对皮肤癌的发展没有预防作用。
J Dtsch Dermatol Ges. 2022 Feb;20(2):157-166. doi: 10.1111/ddg.14649. Epub 2022 Jan 27.
5
Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5.通过抑制环氧化酶-2治疗光化性角化病：二氯芬酸钠 3%在透明质酸 2.5 中的作用机制。
Dermatol Ther. 2019 May;32(3):e12800. doi: 10.1111/dth.12800. Epub 2019 Apr 9.
6
Aspirin and nonsteroidal anti-inflammatory drugs can prevent cutaneous squamous cell carcinoma: a systematic review and meta-analysis.阿司匹林和非甾体抗炎药可预防皮肤鳞状细胞癌：系统评价和荟萃分析。
J Invest Dermatol. 2015 Apr;135(4):975-983. doi: 10.1038/jid.2014.531. Epub 2014 Dec 18.
7
Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.水飞蓟宾及其2,3-脱氢衍生物通过抑制促有丝分裂信号传导和转录因子激活来抑制基底细胞癌的生长。
Mol Carcinog. 2016 Jan;55(1):3-14. doi: 10.1002/mc.22253. Epub 2014 Dec 9.
非甾体抗炎药与皮肤癌风险：基于人群的病例对照研究。
Cancer. 2012 Oct 1;118(19):4768-76. doi: 10.1002/cncr.27406. Epub 2012 May 29.
4
Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.每日阿司匹林对癌症转移风险的影响：随机对照试验中癌症发病的研究。
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5
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6
A systematic review of worldwide incidence of nonmelanoma skin cancer.一项全球范围内非黑色素瘤皮肤癌发病率的系统回顾。
Br J Dermatol. 2012 May;166(5):1069-80. doi: 10.1111/j.1365-2133.2012.10830.x.
7
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8
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9
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10
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