瘤内 5-氟尿嘧啶治疗非黑素瘤皮肤癌：系统评价。

Intralesional 5-Fluorouracil for Treatment of Non-Melanoma Skin Cancer: A Systematic Review.

出版信息

J Drugs Dermatol. 2021 Feb 1;20(2):192-198. doi: 10.36849/JDD.5518.

Abstract

BACKGROUND

Surgical excision is the paradigm treatment option for non-melanoma skin cancer (NMSC), however intralesional fluorouracil (IL 5-FU) is an efficacious alternative and superior to other chemotherapy agents in NMSC. Yet, little summative data exists on the topic.

OBJECTIVE

To assess the efficacy of IL 5-FU in the treatment of NMSC.

METHODS AND MATERIALS

A systematic review was performed using PubMed, Embase and Web of Science databases. 19 studies were included. ANOVA test was used to compare the duration of lesion prior to therapy and resolution time following IL 5-FU treatment. A two-way proportion test was performed to compare the clearance rate between squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and keratoacanthoma (KA).

RESULTS

There was no significant difference between the clearance rate of SCC and BCC after IL 5-FU therapy (87 % vs 91.4%, respectively; P=0.2); however, the clearance rate of both SCC and BCC was significantly greater than that of KA (74.5%; P<0.007); 95% CI [2.56%–19.1%]. Lesion duration and resolution time did not significantly differ across SCC, BCC, and KA (P>0.3).

CONCLUSION

While majority of data is derived from individual cases, IL 5-FU achieved higher clearance rate in SCC and BCC groups than in KA group. J Drugs Dermatol. 2021;20(2):192-198. doi:10.36849/JDD.5518.

摘要

背景

手术切除是非黑素瘤皮肤癌（NMSC）的典型治疗选择，但瘤内氟尿嘧啶（IL 5-FU）是一种有效的替代方案，在 NMSC 中优于其他化疗药物。然而，关于这个主题的综合数据很少。

目的

评估 IL 5-FU 在 NMSC 治疗中的疗效。

方法和材料

使用 PubMed、Embase 和 Web of Science 数据库进行系统评价。纳入 19 项研究。采用方差分析（ANOVA）检验比较治疗前病变持续时间和 IL 5-FU 治疗后缓解时间。采用双向比例检验比较鳞状细胞癌（SCC）、基底细胞癌（BCC）和角化棘皮瘤（KA）之间的清除率。

结果

IL 5-FU 治疗后 SCC 和 BCC 的清除率无显著差异（分别为 87%和 91.4%，P=0.2）；然而，SCC 和 BCC 的清除率均显著高于 KA（74.5%；P<0.007；95%CI [2.56%-19.1%]）。SCC、BCC 和 KA 之间的病变持续时间和缓解时间无显著差异（P>0.3）。