Cherif S, Danino S, Yoganathan K
Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK
Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK.
Int J STD AIDS. 2015 Mar;26(3):206-8. doi: 10.1177/0956462414534396. Epub 2014 May 14.
Hoarseness of voice due to vocal cord paresis as a result of recurrent laryngeal nerve palsy has been well recognised. Recurrent laryngeal nerve palsy is commonly caused by compression due to tumour or lymph nodes or by surgical damage. Vinca alkaloids are well known to cause peripheral neuropathy. However, vinca alkaloids causing recurrent laryngeal nerve palsy has been reported rarely in children. We report a case of an adult patient with HIV who developed hoarseness of voice due to vocal cord paralysis during vinblastine treatment for Hodgkin lymphoma. Mediastinal and hilar lymph node enlargement in such patients may distract clinicians from considering alternative causes of recurrent laryngeal nerve palsy, with potential ensuing severe or even life-threatening stridor.
因喉返神经麻痹导致声带麻痹而引起的声音嘶哑已得到充分认识。喉返神经麻痹通常由肿瘤或淋巴结压迫或手术损伤引起。长春花生物碱众所周知会导致周围神经病变。然而，长春花生物碱导致儿童喉返神经麻痹的报道很少。我们报告一例成年艾滋病患者，在接受长春碱治疗霍奇金淋巴瘤期间因声带麻痹出现声音嘶哑。此类患者的纵隔和肺门淋巴结肿大可能会使临床医生忽略考虑喉返神经麻痹的其他原因，从而可能导致严重甚至危及生命的喘鸣。
