喉切除术后淋巴结阳性喉鳞状细胞癌患者的淋巴结密度作为癌症特异性死亡率的独立预测因素。

Lymph node density as an independent predictor of cancer-specific mortality in patients with lymph node-positive laryngeal squamous cell carcinoma after laryngectomy.

作者信息

Ryu In Sun, Roh Jong-Lyel, Cho Kyung-Ja, Choi Seung-Ho, Nam Soon Yuhl, Kim Sang Yoon

机构信息

Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

出版信息

Head Neck. 2015 Sep;37(9):1319-25. doi: 10.1002/hed.23750. Epub 2014 Jul 19.

DOI:10.1002/hed.23750

PMID:24828891

Abstract

BACKGROUND

We examined the prognostic value of lymph node density in predicting cancer-specific mortality (CSM) for patients with lymph nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy.

METHODS

The records of 156 patients with laryngeal SCC who initially underwent curative resection of the primary tumor combined with neck dissection were reviewed.

RESULTS

The 5-year cumulative incidence of CSM was 20.4%. N classification and extralaryngeal spread (ELS) were independent variables for CSM in all patients. Univariate analyses in 71 pN+ patients showed that ELS, number of positive lymph nodes >4, and lymph node density >0.044 were significantly associated with increased CSM, whereas pN classification was not (p = .218). On multivariate analysis, lymph node density ≥0.044 remained an independent predictor of CSM (p = .001).

CONCLUSION

Among the pN+ patients with laryngeal SCC, no pN classification but lymph node density was noted to have an independent impact on CSM.

摘要

背景

我们研究了淋巴结密度对喉鳞状细胞癌（SCC）患者行喉切除术后淋巴结阳性（pN+）患者癌症特异性死亡率（CSM）的预测价值。

方法

回顾了156例最初接受原发性肿瘤根治性切除联合颈部清扫术的喉SCC患者的记录。

结果

CSM的5年累积发生率为20.4%。N分级和喉外扩散（ELS）是所有患者CSM的独立变量。对71例pN+患者的单因素分析显示，ELS、阳性淋巴结数>4以及淋巴结密度>0.044与CSM增加显著相关，而pN分级则不然（p = 0.218）。多因素分析显示，淋巴结密度≥0.044仍然是CSM的独立预测因素（p = 0.001）。