Department of Otorhinolaryngology and Head Neck Surgery, Ankara Numune Training and Research Hospital, Hacettepe, Talatpaşa Blv No:44, 06230, Altındağ, Ankara, Turkey.
Department of Otorhinolaryngology and Head Neck Surgery, Kecioren Training and Research Hospital, Ankara, Turkey.
Eur Arch Otorhinolaryngol. 2019 Oct;276(10):2923-2927. doi: 10.1007/s00405-019-05560-z. Epub 2019 Jul 17.
To determine the minimum lymph node yield (LNY) in patients with laryngeal squamous cell carcinoma (LSCCs).
This retrospective study was performed in a tertiary care hospital setting and included 42 LSCC patients aged 39-81 years (females, n = 2; males, n = 40) who underwent a total or partial laryngectomy and elective bilateral level II-IV neck dissections (unilateral neck dissections: n = 84).
The average LNY in the unilateral level II-IV lymph node dissections was 25.9 ± 10, and the average metastatic LNY was 0.9 ± 1.9. The unilateral neck dissections were grouped according to the number of lymph nodes. There was no significant difference between the groups in terms of the metastatic LNY (p = 0.5). The metastatic lymph node density (LND) (metastatic lymph node yield/LNY) was 0.043 for unilateral neck level II-IV neck dissections. A Cox regression analysis revealed no significant relationship between survival and the LNY and LND in bilateral neck dissections (p = 0.4 and p = 0.8, respectively).
The results revealed no minimum number of lymph nodes that could reliably detect metastatic lymph nodes in LSCC patients.
确定喉鳞状细胞癌（LSCC）患者的最小淋巴结检出量（LNY）。
这是一项在三级医疗机构进行的回顾性研究，共纳入 42 例年龄为 39-81 岁（女性 n=2；男性 n=40）的 LSCC 患者，所有患者均接受了全喉或部分喉切除术及选择性双侧 II-IV 水平颈淋巴结清扫术（单侧颈清扫术 n=84）。
单侧 II-IV 水平颈淋巴结清扫术的平均 LNY 为 25.9±10，平均转移性 LNY 为 0.9±1.9。单侧颈清扫术根据淋巴结数量进行分组，各组间转移性 LNY 无显著差异（p=0.5）。单侧颈 II-IV 水平颈清扫术的转移性淋巴结密度（LND）（转移性淋巴结检出量/LNY）为 0.043。Cox 回归分析显示，双侧颈清扫术的 LNY 和 LND 与生存率均无显著相关性（p=0.4 和 p=0.8）。
研究结果表明，LSCC 患者中不存在可可靠检测转移性淋巴结的最小淋巴结数量。
