Rabany Liron, Deutsch Lisa, Levkovitz Yechiel
Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel The Emotion-Cognition Research Center, Shalvata Mental Health Care Center, Hod-Hasharon, Israel, which is affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Biostatistical Consulting, BioStats, Modiin, Israel.
J Psychopharmacol. 2014 Jul;28(7):686-90. doi: 10.1177/0269881114533600. Epub 2014 May 14.
Negative symptoms and cognitive deficits are considered core symptoms of schizophrenia, yet treatment for them remains inadequate. Deep-transcranial magnetic stimulation (TMS) is a novel technology that enables non-invasive stimulation of deep layers of the prefrontal cortex. Preliminary evidence suggests that deep-TMS could be effective in the treatment of negative symptoms and cognitive deficits. The current study is the first double-blind, randomized sham-controlled study to examine the feasibility of deep-TMS add-on treatment for negative symptoms and cognitive deficits in schizophrenia. Twenty daily H1 deep-TMS treatments (20Hz, 120% MT) were delivered, in a double-blind, randomized sham-controlled design (n=30). Extensive clinical and cognitive assessments were carried out throughout the study and for an additional one month follow-up period. The results indicate that at the end of the treatment period, negative symptoms (as indicated by the Scale for the Assessment of Negative Symptoms (SANS)) significantly reduced in the TMS group (-7.7), but not in the sham group (-1.9). Differences between the groups were not statistically significant.
阴性症状和认知缺陷被认为是精神分裂症的核心症状，但针对它们的治疗仍然不足。深部经颅磁刺激（TMS）是一种能够对前额叶皮质深层进行非侵入性刺激的新技术。初步证据表明，深部TMS可能对阴性症状和认知缺陷的治疗有效。本研究是第一项双盲、随机、假对照研究，旨在检验深部TMS辅助治疗精神分裂症阴性症状和认知缺陷的可行性。采用双盲、随机、假对照设计（n = 30），进行20次每日H1深部TMS治疗（20Hz，120%运动阈值）。在整个研究过程中以及额外的一个月随访期内进行了广泛的临床和认知评估。结果表明，在治疗期结束时，TMS组的阴性症状（如阴性症状评定量表（SANS）所示）显著减轻（-7.7），而假刺激组则未减轻（-1.9）。两组之间的差异无统计学意义。
