Hung Chien-Chen, Lin Ko-Huan, Chang Hsin-An
Department of Psychiatry, Tzu Chi General Hospital, Hualien 970, Taiwan.
Non-Invasive Neuromodulation Consortium for Mental Disorders, Society of Psychophysiology, Taipei 114, Taiwan.
Medicina (Kaunas). 2024 Dec 14;60(12):2060. doi: 10.3390/medicina60122060.
Cognitive deficits are emerging as critical targets for managing schizophrenia and enhancing clinical and functional outcomes. These deficits are pervasive among individuals with schizophrenia, affecting various cognitive domains. Traditional pharmacotherapy and cognitive behavioral therapy (CBT) have limitations in effectively addressing cognitive impairments in this population. Neuromodulation techniques show promise in improving certain cognitive domains among patients with schizophrenia spectrum disorders. Understanding the mechanisms of neural circuits that underlie cognitive enhancement is essential for elucidating the pathophysiological processes of the disorder, and these insights could significantly optimize strategies for managing schizophrenia. Meanwhile, although there is an increasing body of evidence demonstrating the therapeutic effects of neuromodulation in this area, further research is still needed, particularly regarding topics such as different treatment protocols and the long-term effects of treatment.
认知缺陷正逐渐成为治疗精神分裂症以及改善临床和功能结局的关键靶点。这些缺陷在精神分裂症患者中普遍存在，影响着各个认知领域。传统药物治疗和认知行为疗法（CBT）在有效解决该人群的认知障碍方面存在局限性。神经调节技术在改善精神分裂症谱系障碍患者的某些认知领域方面显示出前景。了解认知增强背后的神经回路机制对于阐明该疾病的病理生理过程至关重要，这些见解可以显著优化精神分裂症的治疗策略。同时，尽管越来越多的证据表明神经调节在该领域的治疗效果，但仍需要进一步研究，特别是关于不同治疗方案和治疗长期效果等主题。
