Fuchs Perry N, Peng Yuan Bo, Boyette-Davis Jessica A, Uhelski Megan L
Department of Psychology, University of Texas at Arlington, Arlington TX, USA ; Department of Biology, University of Texas at Arlington, Arlington TX, USA.
Department of Psychology, University of Texas at Arlington, Arlington TX, USA.
Front Integr Neurosci. 2014 May 5;8:35. doi: 10.3389/fnint.2014.00035. eCollection 2014.
The neural network that contributes to the suffering which accompanies persistent pain states involves a number of brain regions. Of primary interest is the contribution of the cingulate cortex in processing the affective component of pain. The purpose of this review is to summarize recent data obtained using novel behavioral paradigms in animals based on measuring escape and/or avoidance of a noxious stimulus. These paradigms have successfully been used to study the nature of the neuroanatomical and neurochemical contributions of the anterior cingulate cortex (ACC) to higher order pain processing in rodents.
导致持续性疼痛状态所伴随痛苦的神经网络涉及多个脑区。其中主要关注的是扣带回皮质在处理疼痛情感成分方面的作用。本综述的目的是总结近期利用基于测量逃避和/或回避有害刺激的新型动物行为范式所获得的数据。这些范式已成功用于研究啮齿动物前扣带回皮质（ACC）对高阶疼痛处理的神经解剖学和神经化学贡献的性质。
