加巴喷丁用于术后急性疼痛管理
Gabapentin in acute postoperative pain management.
作者信息
Chang Connie Y, Challa Chaitanya K, Shah Janki, Eloy Jean Daniel
机构信息
Department of Anesthesia, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
出版信息
Biomed Res Int. 2014;2014:631756. doi: 10.1155/2014/631756. Epub 2014 Apr 14.
Abstract
Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. Overall, gabapentin has been reported to be a safe and efficacious drug for the treatment of postoperative pain.
摘要
加巴喷丁（1-氨甲基环己烷乙酸）是一种具有神经递质γ-氨基丁酸（GABA）结构的氨基酸。它是一种用于治疗术后疼痛的新型药物，具有抗痛觉过敏特性和独特的作用机制。加巴喷丁以及相关的、效力更强的化合物普瑞巴林已被证明在治疗神经性疼痛以及脊柱手术和子宫切除术后的疼痛方面有益。本研究回顾了加巴喷丁的五个方面：（1）化学和结构特征；（2）药代动力学和药效学；（3）在急性疼痛管理中的应用；（4）不良反应；以及（5）药物安全性。总体而言，据报道加巴喷丁是一种治疗术后疼痛的安全有效的药物。
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