Fredin H, Bergqvist D, Cederholm C, Lindblad B, Nyman U
Lund University Department of Orthopedics, Malmö General Hospital, Sweden.
Acta Orthop Scand. 1989 Dec;60(6):678-81. doi: 10.3109/17453678909149602.
Totally, 150 patients, subjected to total hip arthroplasty, were randomly allocated into three prophylactic groups with either conventional dextran alone or with additional graded compression stockings or with additional preoperative administration of dextran. The overall frequency of deep venous thrombosis (DVT), as studied by radioactive fibrinogen uptake test and ascending phlebography of the operated on thigh was in the conventional dextran group 46 percent, the additional stockinged group 30 percent, and in the additional preoperative dextran group 52 percent. In the stockinged group, there was a lower frequency of DVT in the nonoperated on leg as well as, on an average, about 350 mL less peroperative bleeding as compared with the other two groups. No adverse reaction occurred from dextran administration. Increased and prolonged postoperative administration of dextran decrease the number of femoral DVTs.
总计150例行全髋关节置换术的患者被随机分为三个预防组，分别单独使用传统右旋糖酐、或同时使用分级压力弹力袜、或术前额外给予右旋糖酐。通过放射性纤维蛋白原摄取试验和对手术侧大腿进行上行静脉造影研究发现，传统右旋糖酐组深静脉血栓形成（DVT）的总体发生率为46%，额外使用弹力袜组为30%，术前额外给予右旋糖酐组为52%。与其他两组相比，使用弹力袜组未手术侧下肢DVT发生率较低，且平均术中出血量少约350毫升。右旋糖酐给药未出现不良反应。术后增加并延长右旋糖酐给药可减少股静脉DVT的数量。
