在兔皮下注射聚肌胞苷酸与白蛋白复合物后，血浆干扰素诱导增强。
Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin.
作者信息
Pessina G P, Muscettola M, Paulesu L, Bocci V
机构信息
Institute of General Physiology, University of Siena, Italy.
出版信息
J Biol Regul Homeost Agents. 1989 Jul-Sep;3(3):118-21.
Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
给兔子静脉注射聚肌胞苷酸（poly ICLC）可使血浆干扰素（IFN）水平非常高；每千克体重250至1000微克的剂量毒性很大。与在盐水中的聚肌胞苷酸相比，皮下注射聚肌胞苷酸并同时给予高浓度的人血清白蛋白可增强诱导活性。最后，50微克聚肌胞苷酸溶于12%血清白蛋白中的剂量作为IFN诱导剂比其他剂量更有效。
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