Bever C T, McFarlin D E, Levy H B
Neuroimmunology Branch, NINCDS, NIH, Bethesda, MD.
J Interferon Res. 1992 May;Spec No:85-90. doi: 10.1089/jir.1992.1992.85.
Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS). Patients received intravenous (i.v.) doses of 100 micrograms/kg poly ICLC, and serum IFN levels were determined serially every 4 h for 16 h. Men and women produced substantial levels of IFN at 8, 12, and 16 h after infusion, but levels in men were consistently and significantly higher (p less than 0.05). Interferon responses were examined also in 3 male and 3 female Rhesus monkeys. Serum samples were obtained 8 and 24 h after i.v. injections of 1 mg/kg of poly ICLC. Again, there were significantly higher levels of IFN in males. The observed differences may reflect sex-linked differences in either drug metabolism or specific sensitivity to IFN induction by poly ICLC. The most interesting possibility is that the difference is due to a more general difference in IFN response between males and females. Studies are currently in progress to evaluate these possibilities.
作为对多发性硬化症（MS）患者进行的一项初步试验的一部分，已对6名男性和3名女性针对聚肌胞苷酸（poly ICLC，即聚肌苷酸-聚胞苷酸与聚-L-赖氨酸和羧甲基纤维素的复合物）的干扰素（IFN）反应进行了详细研究。患者静脉注射剂量为100微克/千克的聚ICLC，每隔4小时连续测定血清IFN水平，共持续16小时。男性和女性在输注后8小时、12小时和16小时产生了大量的IFN，但男性的IFN水平始终显著更高（p<0.05）。还对3只雄性和3只雌性恒河猴的干扰素反应进行了检测。静脉注射1毫克/千克聚ICLC后8小时和24小时采集血清样本。同样，雄性动物的IFN水平显著更高。观察到的差异可能反映了药物代谢或对聚ICLC诱导IFN的特异性敏感性方面的性别差异。最有意思的可能性是，这种差异是由于男性和女性在IFN反应方面存在更普遍的差异。目前正在进行研究以评估这些可能性。
