Loewen K G, Derbyshire J B
Department of Veterinary Microbiology and Immunology, University of Guelph, Canada.
Res Vet Sci. 1988 Jan;44(1):132-3.
When newborn piglets were inoculated intravenously with 1.0, 0.5 or 0.25 mg kg-1 of polyinosinic:polycytidylic acid (poly I:C) complexed with poly-L-lysine and carboxymethylcellulose (poly ICLC), the highest serum interferon levels and the lowest white blood cell counts were found in response to a dose of 0.5 mg kg-1. Similar responses were observed in weaned piglets inoculated with 0.25 mg kg-1 of poly ICLC. Poly ICLC was a more effective interferon inducer than poly I:C, particularly in newborn piglets.
当新生仔猪静脉注射与聚-L-赖氨酸和羧甲基纤维素复合的1.0、0.5或0.25毫克/千克聚肌苷酸:聚胞苷酸（聚肌胞苷酸，poly I:C）时，发现剂量为0.5毫克/千克时血清干扰素水平最高，白细胞计数最低。在接种0.25毫克/千克聚肌胞苷酸的断奶仔猪中也观察到类似反应。聚肌胞苷酸比聚肌苷酸:聚胞苷酸是更有效的干扰素诱导剂，尤其在新生仔猪中。
