Roy K K, Subbaiah M, Kumar S, Sharma J B, Singh N
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS) , New Delhi , India.
J Obstet Gynaecol. 2014 Aug;34(6):492-4. doi: 10.3109/01443615.2014.914480. Epub 2014 May 15.
A retrospective analysis of eleven pregnancies complicated by isolated fetal congenital complete heart block (CCHB) in anti-SSA/Ro antibody positive women was carried out at a tertiary hospital in India to study the perinatal outcome. The mean gestational age at the time of detection of fetal CCHB was 24.5 ± 3.1weeks. Six mothers were asymptomatic; two had Sjögren's syndrome and three had systemic lupus erythematosus. Oral dexamethasone was given to all the patients after the diagnosis was made. There was one case of intrauterine death. Seven (63.6%) neonates needed a permanent pacemaker. There was no significant difference in the perinatal outcome in asymptomatic women with fetal CCHB and in women with connective tissue disorder and fetal CCHB. To conclude, fetal CCHB is associated with high morbidity but the presence of underlying connective disorder in the mother does not worsen the prognosis of the affected neonate.
印度一家三级医院对11例抗SSA/Ro抗体阳性女性并发孤立性胎儿先天性完全性心脏传导阻滞（CCHB）的妊娠进行了回顾性分析，以研究围产期结局。检测到胎儿CCHB时的平均孕周为24.5±3.1周。6名母亲无症状；2名患有干燥综合征，3名患有系统性红斑狼疮。诊断后对所有患者给予口服地塞米松。有1例宫内死亡。7名（63.6%）新生儿需要永久性起搏器。胎儿CCHB的无症状女性与结缔组织病合并胎儿CCHB的女性围产期结局无显著差异。总之，胎儿CCHB与高发病率相关，但母亲潜在的结缔组织病不会使受影响新生儿的预后恶化。
