血液及其他体液中基于微小RNA的生物标志物的问题与前景
Issues and prospects of microRNA-based biomarkers in blood and other body fluids.
作者信息
Chevillet John R, Lee Inyoul, Briggs Hilary A, He Yuqing, Wang Kai
机构信息
Institute for Systems Biology, Seattle, WA 98109, USA.
Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10065, USA.
出版信息
Molecules. 2014 May 14;19(5):6080-105. doi: 10.3390/molecules19056080.
Abstract
Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.
摘要
血液中的游离循环微RNA（miRNA）是各种生理病理状况（包括癌症、神经退行性疾病、糖尿病和其他疾病）的良好诊断生物标志物候选物。自2008年它们作为血液生物标志物被发现以来，该领域随着一系列重要发现而迅速扩展。尽管最初对其临床应用潜力持乐观态度，但目前尚无基于循环miRNA的诊断方法在使用。在本文中，我们综述了循环miRNA的现状，研究了不同的分析方法，并探讨了一些挑战和机遇。
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