Universidade de Graz, Áustria.
Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brasil.
Braz J Otorhinolaryngol. 2014 Apr;80(2):111-9. doi: 10.5935/1808-8694.20140025.
There are several materials for reconstruction of nasal dorsum deformities, which are divided into four categories: autologous, homologous, heterologous, and alloplastic grafts.
To compare experimental conditions through inflammatory time reactions in ear cartilage grafts with and without Gelfoam® when grafted on the nasal dorsum of rabbits.
This study included 30 rabbits, divided into two groups of 15 rabbits each (Gelfoam® and cartilage group and cartilage group), and then divided into three sub-groups of 7, 30, and 60 days of follow-up, where the 1.5 cm long and 0.5 wide grafts were placed in the stock grafting on the nasal dorsum of rabbits, half with and half without Gelfoam®. After the specified period, the rabbits in each group were euthanized, and the grafts were then submitted to a histological study.
The experimental group revealed more neovascularization and granulation tissue formation; in terms of the presence of acute and chronic inflammatory process, the results were virtually identical in rabbits from both the control and experimental models in all three groups.
There was no statistical difference to justify the use of Gelfoam® surrounding cartilage graft for nasal dorsum reconstruction.
有几种材料可用于重建鼻背畸形，可分为自体、同种异体、异种和人工合成移植物四类。
比较在兔鼻背移植时带有和不带有 Gelfoam®的耳软骨移植物的炎症时间反应的实验条件。
本研究纳入 30 只兔子，分为两组（Gelfoam®和软骨组及软骨组），每组 15 只，然后分为 7、30 和 60 天三个亚组进行随访，将 1.5 厘米长、0.5 厘米宽的移植物置于兔鼻背的供体移植部位，一半带有 Gelfoam®，一半不带有 Gelfoam®。在指定的时间段后，每组的兔子被安乐死，然后将移植物提交进行组织学研究。
实验组显示出更多的新生血管和肉芽组织形成；在急性和慢性炎症过程的存在方面，三组中来自对照和实验组的兔子的结果几乎相同。
没有统计学差异可以证明在鼻背重建中使用 Gelfoam®环绕软骨移植物是合理的。
