一种来自滇西北蔷薇果实的新型酚酸。
A novel phenolic acid from the fruits of Rosa soulieana.
作者信息
He Wenjun, Yang Chunyan, Wang Mingkui, Li Fu
机构信息
a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , P.R. China.
出版信息
Nat Prod Res. 2014;28(15):1127-33. doi: 10.1080/14786419.2014.915826. Epub 2014 May 15.
From the n-BuOH-soluble fraction of a MeOH extract of the fruits of Rosa soulieana, one new phenolic glucoside (1) was isolated along with five known compounds, comprising two lignin glycosides, two flavonoid glycosides and a phenolic glycoside. The chemical structure of the new compound was elucidated by extensive spectroscopic analyses, including ESI-MS, UV, IR, (1)H and (13)C NMR, DEPT and 2D NMR (HSQC and HMBC). All the isolated compounds were evaluated for their antioxidant activity by using ABTS (2,2'-azino-bis(3-ethylbenzoline-6-sulfonic acid)) assay. Among these compounds, 1, 3 and 6 exhibited strong scavenging activity in ABTS(·+)(SC50 = 102.10, 193.85, 65.38 μmol/L, respectively) compared with the positive control l-ascorbic acid (Vc) (SC50 = 117.16 μmol/L).
从单瓣黄刺玫果实甲醇提取物的正丁醇可溶部分中，分离得到一个新的酚苷（1）以及五个已知化合物，包括两个木脂苷、两个黄酮苷和一个酚苷。通过广泛的光谱分析，包括电喷雾电离质谱（ESI-MS）、紫外光谱（UV）、红外光谱（IR）、氢核磁共振（¹H NMR）、碳核磁共振（¹³C NMR）、无畸变极化转移增强法（DEPT）和二维核磁共振（HSQC和HMBC），阐明了新化合物的化学结构。使用2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）法对所有分离得到的化合物进行抗氧化活性评估。在这些化合物中，与阳性对照l-抗坏血酸（Vc）（半抑制浓度（SC50）=117.16 μmol/L）相比，化合物1、3和6在ABTS阳离子自由基（ABTS(·+)）清除实验中表现出较强的清除活性（SC50分别为102.10、193.85、65.38 μmol/L）。
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