Dunaev V V, Tishkin V S, Evdokimov E I, Belaĭ I M
Farmakol Toksikol. 1989 Nov-Dec;52(6):56-8.
The effect of riboxin (100 mg/kg body weight) on different kinds of metabolism in the cardiac muscles of Wistar rats in norm and during experimental pituitrin-neoepinephrine-induced myocardial infarction was studied. Riboxin was found to stimulate anaerobic glycolysis with the hyperproduction of lactate and the formation of glucose deficiency and also to increase the rate of protein synthesis on polyribosomes. Administration of riboxin during the formation of myocardial infarction considerably hinders the pronounced character of its electrocardiographic and biochemical manifestations. Thus, in the ischemic cardiac muscle the pool of macroergic phosphates is preserved, glycolysis and adaptive protein synthesis are impaired to a lesser degree that probably underlies the cardioprotective effect of riboxin.
研究了核糖核酸（100毫克/千克体重）对正常及实验性垂体后叶素 - 去甲肾上腺素诱导的心肌梗死状态下Wistar大鼠心肌不同代谢类型的影响。发现核糖核酸可刺激无氧糖酵解，导致乳酸大量生成及葡萄糖缺乏，还能提高多核糖体上蛋白质合成的速率。在心肌梗死形成过程中给予核糖核酸，可显著减轻其心电图和生化表现的明显程度。因此，在缺血心肌中，高能磷酸化合物池得以保存，糖酵解和适应性蛋白质合成受损程度较轻，这可能是核糖核酸心脏保护作用的基础。
