Gendenshteĭn E I, Lemkina S M
Farmakol Toksikol. 1988 Mar-Apr;51(2):53-6.
In experiments on 183 rats it was shown that cordarone, anapriline, dimedrol and riboxine increasing in experimental cardiac insufficiency tolerance to the cardiotoxic effect of strophanthin differ significantly by their influence on the hemodynamic effects of this cardiac glycoside. Cordarone increased intensity of the hemodynamic effects of strophanthin and accelerated their development. Under the action of anapriline and dimedrol the stimulating effect of strophanthin on hemodynamics decreased to a much lesser degree than its cardiotoxicity. Riboxine virtually abolished the hemodynamic effects of strophanthin.
在对183只大鼠进行的实验中发现，乙胺碘呋酮、心得安、苯海拉明和核糖核酸在实验性心功能不全时可增强对毒毛花苷心脏毒性作用的耐受性，它们对这种强心苷的血流动力学效应的影响差异显著。乙胺碘呋酮增强了毒毛花苷的血流动力学效应强度并加速其发展。在心得安和苯海拉明作用下，毒毛花苷对血流动力学的刺激作用减弱程度远小于其心脏毒性。核糖核酸实际上消除了毒毛花苷的血流动力学效应。
