Singh Kanwar P, Sharma Aditya M
University of Virginia Health System, Charlottesville, VA, USA,
J Cardiovasc Transl Res. 2014 Jun;7(4):437-45. doi: 10.1007/s12265-014-9562-8. Epub 2014 May 15.
Patients with critical limb ischemia (CLI) represent the highest risk patients with peripheral artery disease (PAD), with high rates of death, amputation, and other cardiovascular events. Previously, nonsurgical options for patients with CLI were limited. However, advances in endovascular techniques such as angiosome-based revascularization and technologies such as drug-eluting balloon and stent platforms have dramatically improved the therapeutic outlook. Additionally, advances in stem cell-based therapy and angiogenic factors show promise as adjuvant medical therapy.
严重肢体缺血（CLI）患者是外周动脉疾病（PAD）中风险最高的患者群体，其死亡率、截肢率和其他心血管事件发生率都很高。以前，CLI患者的非手术治疗选择有限。然而，诸如基于血管单元的血运重建等血管内技术以及药物洗脱球囊和支架平台等技术的进步显著改善了治疗前景。此外，基于干细胞的治疗和血管生成因子的进展有望成为辅助药物治疗手段。
