Jahani Mozhgan, Rezazadeh Davood, Mohammadi Parisa, Abdolmaleki Amir, Norooznezhad Amir, Mansouri Kamran
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Molecular Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Adv Pharm Bull. 2020 Sep;10(4):490-501. doi: 10.34172/apb.2020.061. Epub 2020 Aug 9.
Blood vessel development is one of the most prominent steps in regenerative medicine due to the restoration of blood flow to the ischemic tissues and providing the rapid vascularization in clinical-sized tissue-engineered grafts. However, currently tissue engineering technique is restricted because of the inadequate tissue vascularization. Some challenges like as transportation in large scale, distribution of the nutrients and poor oxygen diffusion limit the progression of vessels in smaller than clinically relevant dimensions as well integration. In this regard, the scholars attempted to promote the vascularization process relied on the stem cells (SCs), growth factors as well as exosomes and interactions of biomaterials with all of them to enable the emergence of ideal microenvironment which is needed for treatment of unhealthy organs or tissue regeneration and formation of new blood vessels. Thus, in the present review we aim to describe these approaches, advances, obstacles and opportunities as well as their application in regeneration of heart as a prominent angiogenesis-dependent organ.
血管生成是再生医学中最突出的步骤之一，因为它能恢复缺血组织的血流，并在临床规模的组织工程移植物中实现快速血管化。然而，目前由于组织血管化不足，组织工程技术受到限制。一些挑战，如大规模运输、营养物质分布和氧气扩散不良，限制了小于临床相关尺寸的血管的进展以及整合。在这方面，学者们试图依靠干细胞、生长因子以及外泌体，以及生物材料与它们的相互作用来促进血管生成过程，以形成治疗不健康器官或组织再生及新血管形成所需的理想微环境。因此，在本综述中，我们旨在描述这些方法、进展、障碍和机遇，以及它们在作为一个突出的依赖血管生成的器官——心脏再生中的应用。
