Saberianpour Shirin, Heidarzadeh Morteza, Geranmayeh Mohammad Hossein, Hosseinkhani Hossein, Rahbarghazi Reza, Nouri Mohammad
1Stem Cell Research Center, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St, Tabriz, 5166614756 Iran.
2Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
J Biol Eng. 2018 Dec 27;12:36. doi: 10.1186/s13036-018-0133-4. eCollection 2018.
Angiogenesis is touted as a fundamental procedure in the regeneration and restoration of different tissues. The induction of de novo blood vessels seems to be vital to yield a successful cell transplantation rate loaded on various scaffolds. Scaffolds are natural or artificial substances that are considered as one of the means for delivering, aligning, maintaining cell connection in a favor of angiogenesis. In addition to the potential role of distinct scaffold type on vascularization, the application of some strategies such as genetic manipulation, and conjugation of pro-angiogenic factors could intensify angiogenesis potential. In the current review, we focused on the status of numerous scaffolds applicable in the field of vascular biology. Also, different strategies and priming approaches useful for the induction of pro-angiogenic signaling pathways were highlighted.
血管生成被视为不同组织再生和修复的基本过程。诱导新生血管对于在各种支架上实现成功的细胞移植率似乎至关重要。支架是天然或人工物质，被认为是促进血管生成的一种用于递送、排列和维持细胞连接的手段。除了不同类型支架在血管化方面的潜在作用外，一些策略（如基因操作和促血管生成因子的结合）的应用可以增强血管生成潜力。在本综述中，我们聚焦于血管生物学领域中众多适用支架的现状。此外，还强调了有助于诱导促血管生成信号通路的不同策略和预处理方法。
