Liu Yi, Guo Zhen, Chen Qing, Wang Suping
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China. Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Mar;35(3):312-6.
To explore the association between TNF-α gene 308 locus polymorphism and the risk of chronic HBV infection in Chinese population.
PubMed,Embase, CNKI and SinoMed database were searched for relevant articles published from January 2001 to May 2013. Case-control studies on TNF-α-308 polymorphism with chronic HBV infection in Chinese population were gathered with meta-analysis applied for calculation of pooled OR value(with 95% CI)after data abstraction.
Eleven case-control studies for the TNF-α-308 polymorphism with a total of 1 872 cases and 1 471 controls were included. Results from the overall meta-analysis indicated that -308A allele had a significant decreased risk of chronic HBV infection (A vs. G:OR = 0.579, 95%CI:0.422-0.794; GA vs. GG:OR = 0.525, 95%CI:0.325-0.847; AA vs. GG:OR = 0.301, 95%CI: 0.125-0.720; GA+AA vs. GG: OR = 0.490, 95%CI:0.309-0.777; AA vs. GA+GG: OR = 0.542, 95% CI:0.394-0.746). In subgroup analyses by region, a significantly decreased risk seemed associated with -308A allele in population from northern China. When stratified by case type, control type and genotyping methods, there appeared no significant association between TNF-α-308A allele and chronic HBV infection in the studies when spontaneously recovered one's were used as controls and PCR used as its methodology.
TNF-α-308A allele seemed a protective factor for chronic HBV infection in the Chinese population.
探讨中国人群中肿瘤坏死因子-α（TNF-α）基因308位点多态性与慢性乙型肝炎病毒（HBV）感染风险之间的关联。
检索PubMed、Embase、中国知网（CNKI）和中国生物医学文献数据库（SinoMed）中2001年1月至2013年5月发表的相关文章。收集关于中国人群中TNF-α-308多态性与慢性HBV感染的病例对照研究，数据提取后采用Meta分析计算合并比值比（OR值）及其95%置信区间（CI）。
纳入11项关于TNF-α-308多态性的病例对照研究，共1872例病例和1471例对照。总体Meta分析结果表明，-308A等位基因使慢性HBV感染风险显著降低（A与G相比：OR = 0.579，95%CI：0.422 - 0.794；GA与GG相比：OR = 0.525，95%CI：0.325 - 0.847；AA与GG相比：OR = 0.301，95%CI：0.125 - 0.720；GA + AA与GG相比：OR = 0.490，95%CI：0.309 - 0.777；AA与GA + GG相比：OR = 0.542，95%CI：0.394 - 0.746）。按地区进行亚组分析时，中国北方人群中-308A等位基因似乎与感染风险显著降低有关。按病例类型、对照类型和基因分型方法分层时，当以自发康复者作为对照且采用聚合酶链反应（PCR）作为基因分型方法时，研究中TNF-α-308A等位基因与慢性HBV感染之间未显示出显著关联。
TNF-α-308A等位基因似乎是中国人群慢性HBV感染的一个保护因素。
