Tang Lude, Zhang Yanjun, Gao Xiaomeng, Dong Rui, Zhang Xifeng, Gu Hongxi, Shang Qinglong
Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Department of Microbiology, Harbin Medical University, Harbin 150081, China. Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Mar;35(3):317-21.
To investigate the relationship between Helicobacter pylori (HP) infection and the development of chronic urticaria.
Published case-control studies which concerned HP infection related chronic urticaria were searched in Wanfang, CNKI, CQVIP Chinese databanks and PubMed. Meta-analysis was applied to analyze the pooled odds ratio (OR) and 95% confidence interval (CI).
37 studies which comprised 2 909 cases of chronic urticaria and 1 873 persons served as controls were enrolled. When compared with the controls, HP infection significantly increased the risk of chronic urticaria development with a pooled OR of 3.20 (95% CI: 2.31-4.43). Results from Meta-regression analyses showed that the distribution of residential areas and detection method being used were potential influential factors.
HP infection seemed to be associated with an increased risk of developing the chronic urticaria.
探讨幽门螺杆菌（HP）感染与慢性荨麻疹发病之间的关系。
在万方、知网、维普中文数据库以及PubMed中检索已发表的有关HP感染相关性慢性荨麻疹的病例对照研究。采用Meta分析方法分析合并比值比（OR）及95%置信区间（CI）。
纳入37项研究，其中包括2909例慢性荨麻疹患者及1873例对照。与对照组相比，HP感染显著增加慢性荨麻疹发病风险，合并OR为3.20（95%CI：2.31-4.43）。Meta回归分析结果显示，居住地区分布及所采用的检测方法为潜在影响因素。
HP感染似乎与慢性荨麻疹发病风险增加有关。
