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感染与胰腺癌风险:一项荟萃分析。

infection and pancreatic cancer risk: A meta-analysis.

作者信息

Guo Yu, Liu Wei, Wu Jun

机构信息

Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, P.R. China.

出版信息

J Cancer Res Ther. 2016 Dec;12(Supplement):C229-C232. doi: 10.4103/0973-1482.200744.

Abstract

OBJECTIVE

To assess whether the Helicobacter pylori (HP) infection can increase the risk of developing pancreatic cancer or not by meta-analysis.

METHODS

Published studies about HP infection and pancreatic cancer risk were electronic searched in the databases of MEDLINE, PubMed, Web of Science, and CNKI. The correlation between HP infection and pancreatic cancer was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot and Egger's linear regression test.

RESULTS

We finally included eight case-control studies for this present meta-analysis with 1003 pancreatic cancer patients and 1754 healthy controls. One study performed in Austria, 3 from China, and 4 from the United States. For obvious statistical heterogeneity, the data were pooled by random effects model. The pooled data indicated that significant correlation between HP infection and pancreatic cancer was found with OR = 1.45 (95% CI = 1.09-1.92) under the random effects model. The results indicated that the HP infection can significantly increase the risk of developing pancreatic cancer. The publication bias was evaluated by Begg's funnel plot and Egger's linear regression test. The Begg's funnel plot was significant asymmetric at the bottom which indicated potential publication bias. The Egger's linear regression test also indicated significant publication bias (t = 3.21, P < 0.05).

CONCLUSION

Based on present open published data, HP infection can significantly increase the risk of developing pancreatic cancer. However, for small number of studies included in this meta-analysis and publication bias, more case-control or cohort studies are needed to further confirm this conclusion.

摘要

目的

通过荟萃分析评估幽门螺杆菌(HP)感染是否会增加患胰腺癌的风险。

方法

在MEDLINE、PubMed、科学网和中国知网数据库中对已发表的关于HP感染与胰腺癌风险的研究进行电子检索。通过比值比(OR)及相应的95%置信区间(CI)来证明HP感染与胰腺癌之间的相关性。采用Begg漏斗图和Egger线性回归检验评估发表偏倚。

结果

我们最终纳入了八项病例对照研究进行本次荟萃分析,其中有1003例胰腺癌患者和1754例健康对照。一项研究来自奥地利,三项来自中国,四项来自美国。由于存在明显的统计学异质性,数据采用随机效应模型进行合并。合并数据表明,在随机效应模型下,HP感染与胰腺癌之间存在显著相关性,OR = 1.45(95%CI = 1.09 - 1.92)。结果表明,HP感染可显著增加患胰腺癌的风险。采用Begg漏斗图和Egger线性回归检验评估发表偏倚。Begg漏斗图底部明显不对称,表明存在潜在的发表偏倚。Egger线性回归检验也表明存在显著的发表偏倚(t = 3.21,P < 0.05)。

结论

基于目前公开的已发表数据,HP感染可显著增加患胰腺癌的风险。然而,由于本荟萃分析纳入的研究数量较少且存在发表偏倚,需要更多的病例对照或队列研究来进一步证实这一结论。

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