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器官短缺:移植医学面临的最大挑战。

Organ shortage: the greatest challenge facing transplant medicine.

作者信息

Shafran David, Kodish Eric, Tzakis Andreas

机构信息

Department of Bioethics and the Transplant Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA,

出版信息

World J Surg. 2014 Jul;38(7):1650-7. doi: 10.1007/s00268-014-2639-3.

DOI:10.1007/s00268-014-2639-3
PMID:24831673
Abstract

The success of organ transplantation as a treatment for end-stage organ disease has yielded a series of ethical quandaries originating from the issue of organ shortage. Scarcity of organs for transplantation necessitates formulation of just and fair allocation policies as well as ethically viable solutions to bridging the vast gap between organ supply and demand. The concept of "triage" provides a useful paradigm in which to contextualize the organ shortage issue. This entails subjugating the welfare of the individual patient for the benefit of the wider community as an ethically justified response to the challenge of scarcity.

摘要

器官移植作为终末期器官疾病的一种治疗方法取得成功后,引发了一系列源于器官短缺问题的伦理困境。移植器官的稀缺使得必须制定公正公平的分配政策,以及从伦理角度可行的解决方案,以弥合器官供需之间的巨大差距。“分诊”概念为将器官短缺问题置于具体情境提供了一个有用的范例。这意味着为了更广泛的社区利益而牺牲个体患者的福祉,作为对稀缺挑战的一种伦理上合理的应对措施。

相似文献

1
Organ shortage: the greatest challenge facing transplant medicine.器官短缺:移植医学面临的最大挑战。
World J Surg. 2014 Jul;38(7):1650-7. doi: 10.1007/s00268-014-2639-3.
2
Fair distribution and patients who receive more than one organ transplant.公平分配与接受多个器官移植的患者。
J Clin Ethics. 2002 Spring;13(1):40-8.
3
Make it so!: advocating for UNOS policy change.就这样定了!:倡导器官共享联合网络(UNOS)的政策变革。
Am J Bioeth. 2005 Fall;5(4):21-2. doi: 10.1080/15265160500194212.
4
[Allocation of donated organs for transplantation: what is fair?].[用于移植的捐赠器官分配:何为公平?]
Dtsch Med Wochenschr. 2013 Sep;138(38):1902-4. doi: 10.1055/s-0033-1343299. Epub 2013 Sep 10.
5
Organ transplantation: an ethical road map.器官移植:一份伦理路线图。
Natl Cathol Bioeth Q. 2002 Autumn;2(3):413-53. doi: 10.5840/ncbq20022331.
6
Is the adoption of more efficient strategies of organ procurement the answer to persistent organ shortage in transplantation?采用更高效的器官获取策略是否能解决移植中持续存在的器官短缺问题?
Bioethics. 1992 Apr;6(2):113-29. doi: 10.1111/j.1467-8519.1992.tb00190.x.
7
UNOS: the faithless trustee.器官共享联合网络:背信弃义的受托人。
Am J Bioeth. 2005 Fall;5(4):13-4. doi: 10.1080/15265160500193750.
8
A fair distribution of organs for transplantation purposes: looking to the past and the future.用于移植目的的器官公平分配:回顾过去与展望未来。
Eur J Health Law. 2007 Nov;14(3):215-9. doi: 10.1163/092902707x232962.
9
On the possibility of "progress" in managing biomedical technologies: markets, lotteries, and rational moral standards in organ transplantation.论生物医学技术管理中“进步”的可能性:器官移植中的市场、抽签与合理道德标准
Cap Univ Law Rev. 2003;31(1):13-69.
10
A matter of priority: transplanting organs preferentially to registered donors.优先事项:优先向登记捐赠者移植器官。
Rutgers Law Rev. 2003 Spring;55(3):671-740.

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The Effect of Early Spironolactone Administration on 2-Year Acute Graft Rejection in Cardiac Transplant Patients.早期使用螺内酯对心脏移植患者2年急性移植物排斥反应的影响。
Biomedicines. 2025 May 10;13(5):1164. doi: 10.3390/biomedicines13051164.
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Application potential of senolytics in clinical treatment.衰老细胞清除剂在临床治疗中的应用潜力。
Biogerontology. 2024 Jun;25(3):379-398. doi: 10.1007/s10522-023-10084-5. Epub 2023 Dec 18.
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The role of healthcare professionals to improve organ donation and transplantation outcome: a national study.

本文引用的文献

1
Consent to organ donation: a review.器官捐赠同意书:综述
Prog Transplant. 2013 Mar;23(1):99-104. doi: 10.7182/pit2013801.
2
Kidney, pancreas and liver allocation and distribution in the United States.美国的肾脏、胰腺和肝脏分配与分布。
Am J Transplant. 2012 Dec;12(12):3191-212. doi: 10.1111/j.1600-6143.2012.04259.x. Epub 2012 Nov 16.
3
Lung and heart allocation in the United States.美国的肺脏和心脏分配。
医疗保健专业人员在改善器官捐献和移植结果中的作用:一项全国性研究。
Cell Tissue Bank. 2024 Mar;25(1):159-165. doi: 10.1007/s10561-023-10071-7. Epub 2023 Jan 28.
4
Current status of xenotransplantation research and the strategies for preventing xenograft rejection.异种移植研究的现状与防止异种移植物排斥反应的策略。
Front Immunol. 2022 Jul 28;13:928173. doi: 10.3389/fimmu.2022.928173. eCollection 2022.
5
Endovascular stenting with a drug-eluting stent of transplanted renal artery stenosis in a dual kidney transplanted patient.双肾移植患者移植肾动脉狭窄的药物洗脱支架血管内支架置入术。
J Vasc Bras. 2021 Nov 29;20:e20210054. doi: 10.1590/1677-5449.210054. eCollection 2021.
6
Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure.异位肝细胞移植的细胞疗法治疗急性肝衰竭的猪酪氨酸血症模型。
Mol Ther Methods Clin Dev. 2020 Jul 10;18:738-750. doi: 10.1016/j.omtm.2020.07.009. eCollection 2020 Sep 11.
7
Relaxin Positively Influences Ischemia-Reperfusion Injury in Solid Organ Transplantation: A Comprehensive Review.松弛素对实体器官移植中缺血再灌注损伤的影响:全面综述。
Int J Mol Sci. 2020 Jan 17;21(2):631. doi: 10.3390/ijms21020631.
8
Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.儿科器官移植列入名单决策中遗传风险的应用:一项全国性调查。
Pediatr Transplant. 2019 Jun;23(4):e13402. doi: 10.1111/petr.13402. Epub 2019 Apr 23.
9
Randomised controlled trial of the impact of haemodiafiltration on uraemic neuropathy: FINESSE study protocol.随机对照试验研究血液透析滤过对尿毒症性神经病的影响:FINESSE 研究方案。
BMJ Open. 2019 Jan 15;9(1):e023736. doi: 10.1136/bmjopen-2018-023736.
10
Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1.通过体细胞核移植技术生成 GGTA1 敲除猪,表达可溶性人 TNFRI-Fc 和人 HO-1。
Transgenic Res. 2019 Feb;28(1):91-102. doi: 10.1007/s11248-018-0103-0. Epub 2018 Dec 14.
Am J Transplant. 2012 Dec;12(12):3213-34. doi: 10.1111/j.1600-6143.2012.04258.x. Epub 2012 Sep 13.
4
Live donor champion: finding live kidney donors by separating the advocate from the patient.活体供者的倡导者:将倡导者与患者分开,寻找活体肾脏供者。
Transplantation. 2012 Jun 15;93(11):1147-50. doi: 10.1097/TP.0b013e31824e75a5.
5
Current status of organ transplantation in Japan.日本器官移植的现状。
Am J Transplant. 2012 Mar;12(3):523-30. doi: 10.1111/j.1600-6143.2011.03822.x. Epub 2011 Nov 4.
6
Arguments against promoting organ transplants from brain-dead donors, and views of contemporary Japanese on life and death.反对宣传脑死亡供体器官移植的论点,以及当代日本人对生死的看法。
Bioethics. 2012 May;26(4):215-23. doi: 10.1111/j.1467-8519.2010.01839.x. Epub 2010 Aug 23.
7
Organ trafficking: global solutions for a global problem.器官贩卖:全球性问题的全球解决方案。
Am J Kidney Dis. 2009 Dec;54(6):1145-57. doi: 10.1053/j.ajkd.2009.08.014. Epub 2009 Oct 31.
8
The ethics of organ transplantation: shortages and strategies.器官移植的伦理:短缺与策略。
Ann Acad Med Singap. 2009 Apr;38(4):359-6.
9
Principles for allocation of scarce medical interventions.稀缺医疗干预措施的分配原则。
Lancet. 2009 Jan 31;373(9661):423-31. doi: 10.1016/S0140-6736(09)60137-9.
10
The Declaration of Istanbul on organ trafficking and transplant tourism.《关于器官买卖和移植旅游的伊斯坦布尔宣言》
Transplantation. 2008 Oct 27;86(8):1013-8. doi: 10.1097/TP.0b013e318185ffc9.