Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan.
Br J Ophthalmol. 2014 Oct;98(10):1442-7. doi: 10.1136/bjophthalmol-2014-304946. Epub 2014 May 15.
To describe a surgical procedure for excising the eyelash line to treat cilial entropion in patients with Down's syndrome.
24 Down's patients with cilial entropion and medial epiblepharon underwent eyelash line resection bilaterally. The area and density of fluorescein staining of the superficial punctate keratopathy (SPK; 0=none to 3=wide or severe) and the frequency of spectacle wear (0=no wear to 2=all day wear) were evaluated prospectively.
The postoperative area and density of the SPK improved significantly in both eyes (p<0.001, p<0.001). The score of spectacle wear was 1.3 ± 0.8 preoperatively which improved significantly to 1.7 ± 0.5 after surgery (p=0.018). Five patients had a partial recurrence of misdirected eyelashes adjacent to the site of the excision. Two patients had extended excisions of the misdirected eyelashes 3 years after the initial surgery, and they did not have any further recurrences. Three other patients were followed without additional treatment because lacrimation and eye discharge were mild even with some eyelashes misdirected toward cornea.
Eyelash line resection is a simple and effective technique for cilial entropion and medial epiblepharon in patients with Down's syndrome. The surgery improves the SPK and frequency of spectacle wear.
NCT01758718.
描述一种通过切除睫毛线治疗唐氏综合征患者倒睫和内眦赘皮的手术方法。
24 例唐氏综合征倒睫和内眦赘皮患者行双侧睫毛线切除术。前瞻性评估浅层点状角膜病变（SPK；0=无至 3=广泛或严重）的荧光素染色面积和密度（0=无至 3=广泛或严重）以及戴镜频率（0=不戴至 2=全天戴）。
双眼术后 SPK 的面积和密度均显著改善（p<0.001，p<0.001）。术前戴镜评分 1.3±0.8，术后显著改善至 1.7±0.5（p=0.018）。5 例患者切除部位附近有部分睫毛重新倒向。2 例患者在初次手术后 3 年进行了延长的倒睫切除，此后无进一步复发。另外 3 例患者未接受额外治疗，因为即使有一些睫毛向角膜方向倒向，流泪和眼分泌物也很轻微。
对于唐氏综合征患者的倒睫和内眦赘皮，睫毛线切除术是一种简单有效的治疗方法。手术可改善 SPK 和戴镜频率。
NCT01758718。
