冠状动脉疾病和心力衰竭中的心血管重塑
Cardiovascular remodelling in coronary artery disease and heart failure.
作者信息
Heusch Gerd, Libby Peter, Gersh Bernard, Yellon Derek, Böhm Michael, Lopaschuk Gary, Opie Lionel
机构信息
Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Lancet. 2014 May 31;383(9932):1933-43. doi: 10.1016/S0140-6736(14)60107-0. Epub 2014 May 13.
Abstract
Remodelling is a response of the myocardium and vasculature to a range of potentially noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, compensatory, and adaptive but, when sustained, progresses to structural changes that become self-perpetuating and pathogenic. Remodelling involves responses not only of the cardiomyocytes, endothelium, and vascular smooth muscle cells, but also of interstitial cells and matrix. In this Review we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure, and we draw attention to potential avenues for innovative therapeutic approaches, including conditioning and metabolic strategies.
摘要
重塑是心肌和血管对一系列潜在有害的血流动力学、代谢和炎症刺激的反应。重塑最初是功能性的、代偿性的和适应性的，但如果持续存在，就会发展为结构变化，这些变化会自我延续并导致疾病。重塑不仅涉及心肌细胞、内皮细胞和血管平滑肌细胞的反应，还涉及间质细胞和基质的反应。在本综述中，我们描述了动脉粥样硬化、血管和心肌缺血再灌注损伤以及心力衰竭中的重塑过程，并提请注意创新治疗方法的潜在途径，包括预处理和代谢策略。
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Circulation. 2013 Oct 22;128(17):1889-96. doi: 10.1161/CIRCULATIONAHA.113.001690. Epub 2013 Sep 25.
2
Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention.经皮冠状动脉介入治疗联合远程缺血预处理可改善 ST 段抬高型心肌梗死患者的长期临床预后。
Eur Heart J. 2014 Jan;35(3):168-75. doi: 10.1093/eurheartj/eht369. Epub 2013 Sep 12.
3
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4
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Circulation. 2013 Oct 1;128(14):1495-503. doi: 10.1161/CIRCULATIONAHA.113.003653. Epub 2013 Sep 3.
5
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7
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