Yang Bo, Liu Chao, Diao Lanping, Wang Cuiju, Guo Zhanjun
Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, China.
Cancer Genet. 2014 Apr;207(4):141-6. doi: 10.1016/j.cancergen.2014.03.007. Epub 2014 Mar 22.
MicroRNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs, where they interfere with translation and thereby regulate cell differentiation, apoptosis, and tumorigenesis. Genetic polymorphisms in the 3' UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. In this study, four miRNA binding-site single nucleotide polymorphisms (SNPs) located in the 3' UTR of RYR3 (rs1044129), C14orf101 (rs4901706), KIAA0423 (rs1053667), and GOLGA7 (rs11337) were genotyped in non-Hodgkin lymphoma (NHL) patients to assess their relationships with cancer risk and overall survival. rs4901706, located in the 3' UTR of C14orf101, was shown to be independently related to overall survival in NHL patients by multivariate analysis (relative risk, 1.770; 95% CI, 1.046-2.996; P = 0.033). The prognostic value of this SNP on tumor overall survival was supported in diffuse large B-cell lymphoma patients with a P value of 0.095 and validated in T-cell lymphoma patients with a P value of 0.037.
微小RNA（miRNA）可与信使核糖核酸（mRNA）的3'非翻译区（UTR）结合，在该区域它们会干扰翻译过程，从而调节细胞分化、凋亡和肿瘤发生。miRNA靶向的3'UTR中的基因多态性会以影响单个miRNA行为的方式改变miRNA结合的强度。在本研究中，对非霍奇金淋巴瘤（NHL）患者中位于RYR3（rs1044129）、C14orf101（rs4901706）、KIAA0423（rs1053667）和GOLGA7（rs11337）的3'UTR中的四个miRNA结合位点单核苷酸多态性（SNP）进行了基因分型，以评估它们与癌症风险和总生存期的关系。位于C14orf101的3'UTR中的rs4901706经多变量分析显示与NHL患者的总生存期独立相关（相对风险，1.770；95%置信区间，1.046 - 2.996；P = 0.033）。该SNP对肿瘤总生存期的预后价值在弥漫性大B细胞淋巴瘤患者中得到支持，P值为0.095，并在T细胞淋巴瘤患者中得到验证，P值为0.037。
