miR-125a rs12976445与乳腺癌患者生存率之间的关联。
Association between miR-125a rs12976445 and survival in breast cancer patients.
作者信息
Jiao Lianghe, Zhang Jiaxin, Dong Yuanyuan, Duan Bensong, Yu Hong, Sheng Haihui, Huang Junxing, Gao Hengjun
机构信息
Department of Breast Surgery, Taizhou People's Hospital Taizhou, Jiangsu, China.
Department of Thyroid and Breast Surgery, Subei People's Hospital, Clinical Medical College of Yangzhou University Yangzhou, Jiangsu, China.
出版信息
Am J Transl Res. 2014 Nov 22;6(6):869-75. eCollection 2014.
MicroRNAs (miRNAs) act as an oncogene or a tumor suppressor by negatively regulating target genes. Genetic variants in miRNA genes confer susceptibility to cancer and risk of death in cancer patients. The aim of this study was to investigate whether miRNA polymorphisms were associated with survival in breast cancer patients. Five miRNA polymorphisms (miR-26a1 rs7372209, miR-125a rs12976445, miR-218 rs11134527, miR-423 rs6505162, and miR-608 rs4919510) were genotyped in 196 breast cancer patients. We found that miR-125a rs12976445 was significantly associated with survival in codominant, recessive, and dominant models. However, only association under the codominant model remained significant after adjustment for lymph node metastasis, TNM stage, estrogen receptor, and progesterone receptor. Furthermore, this effect remained in stratification analysis. In conclusion, our results provide evidence that miR-125a rs12976445 may serve as a prognostic biomarker for breast cancer. Further large-scale studies are required to confirm these findings.
微小RNA（miRNA）通过负向调控靶基因发挥癌基因或肿瘤抑制基因的作用。miRNA基因中的遗传变异会使癌症患者易患癌症并增加死亡风险。本研究的目的是调查miRNA多态性是否与乳腺癌患者的生存相关。对196例乳腺癌患者的5种miRNA多态性（miR-26a1 rs7372209、miR-125a rs12976445、miR-218 rs11134527、miR-423 rs6505162和miR-608 rs4919510）进行了基因分型。我们发现，miR-125a rs12976445在共显性、隐性和显性模型中均与生存显著相关。然而，在对淋巴结转移、TNM分期、雌激素受体和孕激素受体进行校正后，仅共显性模型下的关联仍具有显著性。此外，在分层分析中这种效应仍然存在。总之，我们的结果提供了证据表明miR-125a rs12976445可能作为乳腺癌的预后生物标志物。需要进一步的大规模研究来证实这些发现。
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