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[考虑纤维蛋白原水平测定血浆中纤维蛋白单体的可溶性复合物]

[Determination of soluble complexes of fibrin monomers in plasma taking into consideration the fibrinogen level].

作者信息

Ivanov E P, Tsvirko D G, Ivanov V E

出版信息

Lab Delo. 1989(12):38-43.

PMID:2483201
Abstract

Quantitative modifications of beta-naphthol, ethanol, and protamine sulfate tests are described, which are based on spectrophotometry of the formed precipitate. The findings have demonstrated a correlation between these tests' results and the plasma fibrinogen concentration. It is recommended that the paracoagulation test parameters be estimated with consideration for fibrinogen level. The results of measurements of the plasma fibrin monomer soluble complexes in 13 donors and in 72 patients with blood diseases and hemostasis are presented. The results permit a conclusion that these tests used alone or in various combinations are sufficiently sensitive, specific, and informative for the examinations of patients with disseminated intravascular coagulation; combined use of three paracoagulation tests has been found to be optimal.

摘要

本文描述了基于对形成沉淀进行分光光度法的β-萘酚、乙醇和硫酸鱼精蛋白试验的定量改进方法。研究结果表明这些试验结果与血浆纤维蛋白原浓度之间存在相关性。建议在评估副凝血试验参数时考虑纤维蛋白原水平。文中给出了13名献血者以及72名患有血液疾病和止血功能障碍患者的血浆纤维蛋白单体可溶性复合物的测量结果。结果表明,单独使用或组合使用这些试验,对于弥散性血管内凝血患者的检查具有足够的敏感性、特异性和信息价值;已发现联合使用三种副凝血试验是最佳的。

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