Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Curr Opin Biotechnol. 2014 Aug;28:10-6. doi: 10.1016/j.copbio.2013.10.011. Epub 2013 Nov 17.
In an attempt to mimic the biosynthetic efficiencies of nature and in a search for greener, more sustainable alternatives to nowadays ways of producing chemicals, one-pot cascade reactions have attracted a lot of attention in the past decade. Since most catalysts are not compatible with each other, compartmentalization techniques have often been applied to prevent catalyst inactivation. A various array of nanoreactors have been developed to meet the demand of having a site-isolated catalyst system, while maintaining the catalyst activity. Both multienzyme nanoreactors as well as enzyme/metal catalyst or organocatalyst systems have shown great potential in one-pot cascade reactions and hold promise for future developments in this field.
为了模仿自然界的生物合成效率，并寻找比当今生产化学品的方法更绿色、更可持续的替代方法，一锅级联反应在过去十年中引起了广泛关注。由于大多数催化剂彼此不兼容，因此经常采用分隔技术来防止催化剂失活。已经开发出各种纳米反应器来满足具有隔离催化剂体系的需求，同时保持催化剂活性。多酶纳米反应器以及酶/金属催化剂或有机催化剂体系在一锅级联反应中显示出巨大的潜力，并为该领域的未来发展带来了希望。
