弓形虫与宿主干扰素反应的军备竞赛：三种棒状体蛋白的三角关系
Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs.
作者信息
Zhao Yanlin, Yap George S
机构信息
Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA.
Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA.
出版信息
Cell Host Microbe. 2014 May 14;15(5):517-8. doi: 10.1016/j.chom.2014.05.002.
Abstract
The Toxoplasma gondii virulence factors ROP5 and ROP18 both target immunity-related GTPases (IRGs) to evade immunity. In this issue of Cell Host & Microbe, Etheridge et al. (2014) identify a third virulence factor, ROP17, which forms a complex and synergizes with ROP5/ROP18 to fully disable the IRG system of antiparasite defense.
摘要
弓形虫毒力因子ROP5和ROP18均靶向免疫相关GTP酶（IRGs）以逃避免疫。在本期《细胞宿主与微生物》中，埃瑟里奇等人（2014年）鉴定出第三种毒力因子ROP17，它形成一种复合物并与ROP5/ROP18协同作用，从而完全破坏抗寄生虫防御的IRG系统。
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本文引用的文献
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