Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.
Cell Host Microbe. 2014 May 14;15(5):526-36. doi: 10.1016/j.chom.2014.04.011.
Neutrophils are endowed with a plethora of toxic molecules that are mobilized in immune responses. These cells evolved to fight infections, but when deployed at the wrong time and in the wrong place, they cause damage to the host. Here, we review the generalities of these cells as well as the difficulties encountered when trying to unravel them mechanistically. We then focus on how neutrophils develop and their function in infection. We center our attention on human neutrophils and what we learn from clinical immunodeficiencies. Finally, we use autoimmune disease to illustrate the harmful potential of dysregulated neutrophil responses.
中性粒细胞具有多种免疫反应中可被动员的毒性分子。这些细胞的演化目的是对抗感染，但如果在错误的时间和地点被激活，它们会对宿主造成损伤。在这里，我们回顾了这些细胞的一般性特征，以及在试图从机制上阐明它们时所遇到的困难。然后，我们专注于中性粒细胞的发育以及它们在感染中的功能。我们将注意力集中在人类中性粒细胞上，以及我们从临床免疫缺陷中了解到的内容。最后，我们使用自身免疫性疾病来说明失调的中性粒细胞反应的潜在危害。
