Suzuki K, Fujii M, Ishii Y, Mochizuki F, Suzuki K, Yamagata M, Suzuki H, Moriya Y, Abiko Y, Sakabe T
Nichidai Koko Kagaku. 1989 Jun;15(2):157-65.
The radiosensitivity and radio-chemosensitivity of 3 series of human cancer cell lines were evaluated by human tumor clonogenic assay. The sources of cell lines were gingiva carcinoma (Ca9-22), uterus carcinoma (Hela) and gastric carcinoma (MKN-45). BLM and CDDP were used, and chemosensitivity of gingiva carcinoma tended to be higher than other cell lines. Radiosensitivity was same as MKN-45. Isobologram were employed for quantitation of the interaction between the irradiation and anti-cancer agents. In Ca9-22, the interaction of between gamma-rays, BLM and CDDP was supra-additive. Hela was also supra-additive, but in MKN-45, the interaction of between gamma-rays and BLM was sub-additive.
通过人肿瘤克隆形成试验评估了3组人癌细胞系的放射敏感性和放化疗敏感性。细胞系来源为牙龈癌（Ca9-22）、子宫癌（Hela）和胃癌（MKN-45）。使用了博来霉素（BLM）和顺铂（CDDP），牙龈癌的化疗敏感性倾向于高于其他细胞系。放射敏感性与MKN-45相同。采用等效线图定量照射与抗癌药物之间的相互作用。在Ca9-22中，γ射线、BLM和CDDP之间的相互作用是超相加的。Hela也是超相加的，但在MKN-45中，γ射线和BLM之间的相互作用是次相加的。
