Salimzadeh Ahmad, Abolhasani Maryam, Sedaghattalab Moslem, Moghadasi Maryam
Rheumatology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Endocrine and Metabolic Research Center, Obesity Group, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Rheum Dis. 2017 May;20(5):555-560. doi: 10.1111/1756-185X.12400. Epub 2014 May 16.
The presence of a direct relationship between body mass index (BMI) and bone mineral density (BMD) is frequently reported. However, data on the relationship between visceral fat and bone density varies, with positive, negative or no relationship having been reported. This study aims to examine the relationship between abdominal visceral fat and BMD.
A cross sectional study was carried out on 95 premenopausal, overweight and obese women aged 30-50 years referred to Sina Hospital, Tehran, Iran in 2011-2012. Anthropometric indices and visceral fat levels were measured.
Multiple linear regression analysis showed that proximal femur BMD (P = 0.856) and lumbar spine BMD (P = 0.558) were not significantly related to visceral fat level. However, BMI had a direct and significant positive relationship with proximal femur BMD (P = 0.001) and lumbar spine BMD (P = 0.031). Menarche age was negatively related to lumbar spine BMD (P = 0.003).
In this study, after adjusting for fat-free mass, no significant relationship was found between MBD of the proximal femur and lumbar spine, and visceral fat level or visceral fat to total fat percentage ratio. Therefore, abdominal visceral fat may not affect BMD, independent of weight. It seems that the positive relationship between BMI and proximal femur and lumbar spine BMD is due to the mechanical effects of weight on bones.
经常有报道称体重指数（BMI）与骨矿物质密度（BMD）之间存在直接关系。然而，关于内脏脂肪与骨密度之间关系的数据各不相同，有报道称二者呈正相关、负相关或无相关性。本研究旨在探讨腹部内脏脂肪与骨密度之间的关系。
2011年至2012年，对转诊至伊朗德黑兰西娜医院的95名年龄在30至50岁之间的绝经前超重和肥胖女性进行了横断面研究。测量了人体测量指标和内脏脂肪水平。
多元线性回归分析显示，股骨近端骨密度（P = 0.856）和腰椎骨密度（P = 0.558）与内脏脂肪水平无显著相关性。然而，BMI与股骨近端骨密度（P = 0.001）和腰椎骨密度（P = 0.031）呈直接且显著的正相关。初潮年龄与腰椎骨密度呈负相关（P = 0.003）。
在本研究中，在调整去脂体重后，未发现股骨近端和腰椎的骨密度与内脏脂肪水平或内脏脂肪占总脂肪百分比之间存在显著关系。因此，腹部内脏脂肪可能不会独立于体重而影响骨密度。BMI与股骨近端和腰椎骨密度之间的正相关似乎是由于体重对骨骼的机械作用。
