葡萄膜炎患者中弓形虫和犬弓首蛔虫的患病率。

Prevalence of Toxoplasma gondii and Toxocara canis among patients with uveitis.

作者信息

Lim Su Jin, Lee Sang Eun, Kim Sun Hyun, Hong Sung-Hee, You Yong Sung, Kwon Oh Woong, Kim Hyeun Seung

机构信息

The retina center of Nune Eye Hospital , Seoul , Korea .

出版信息

Ocul Immunol Inflamm. 2014 Oct;22(5):360-6. doi: 10.3109/09273948.2013.841491. Epub 2014 May 15.

DOI:10.3109/09273948.2013.841491

PMID:24833105

Abstract

PURPOSE

To investigate the prevalence of Toxoplasma gondii and Toxocara canis in patients with uveitis.

METHOD

Patients with uveitis were examined. Serum antibodies to T. gondii and T. canis were tested by using enzyme-linked immunosorbent assay (ELISA). Polymerase chain reaction (PCR) was done using blood and aqueous humor (AH).

RESULTS

98 patients were enrolled. Mean age was 43.5 ± 13.2 years. Six patients were seropositive for T. gondii with the following pattern-anterior uveitis: 1; posterior uveitis with retinitis: 2; pan uveitis: 2. One patient had a positive result of PCR for T.gondii in AH, who showed pan uveitis. 23 patients were positive to serum IgG for T. canis with the following clinical manifestation-granuloma: 6; pigmented scar: 3; virtrits: 6-but none were PCR positive.

CONCLUSION

T.gondii and T.canis are still one of the important causes of uveitis. Ocular toxocariasis is not an uncommon cause of uveitis even in adult.

摘要

目的

调查葡萄膜炎患者中弓形虫和犬弓首蛔虫的感染率。

方法

对葡萄膜炎患者进行检查。采用酶联免疫吸附测定（ELISA）检测血清中针对弓形虫和犬弓首蛔虫的抗体。使用血液和房水进行聚合酶链反应（PCR）。

结果

纳入98例患者。平均年龄为43.5±13.2岁。6例患者弓形虫血清学阳性，其表现如下：前葡萄膜炎：1例；伴有视网膜炎的后葡萄膜炎：2例；全葡萄膜炎：2例。1例全葡萄膜炎患者房水中弓形虫PCR检测呈阳性。23例患者犬弓首蛔虫血清IgG呈阳性，其临床表现如下：肉芽肿：6例；色素沉着瘢痕：3例；葡萄膜炎：6例，但均无PCR阳性。