Wilder Julius, Patel Keyur
Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA ; Duke Clinical Research Institute, Durham, NC, USA.
Med Devices (Auckl). 2014 May 3;7:107-14. doi: 10.2147/MDER.S46943. eCollection 2014.
An important aspect of managing chronic liver disease is assessing for evidence of fibrosis. Historically, this has been accomplished using liver biopsy, which is an invasive procedure associated with risk for complications and significant sampling and observer error, limiting the accuracy for determination of fibrosis stage. Hence, several serum biomarkers and imaging methods for noninvasive assessment of liver fibrosis have been developed. In this article, we review the current literature on an important noninvasive imaging modality to measure tissue elastography (FibroScan(®)). This ultrasound-based technique is now increasingly available in many countries and has been shown to be a reliable and safe noninvasive means of assessing disease severity in chronic liver disease of varying etiology.
管理慢性肝病的一个重要方面是评估纤维化的证据。从历史上看,这是通过肝活检来完成的,肝活检是一种侵入性操作,存在并发症风险以及显著的取样和观察者误差,限制了纤维化阶段判定的准确性。因此,已经开发了几种用于肝纤维化无创评估的血清生物标志物和成像方法。在本文中,我们回顾了关于一种重要的无创成像方式——组织弹性成像(FibroScan(®))的当前文献。这种基于超声的技术现在在许多国家越来越普及,并且已被证明是评估不同病因慢性肝病疾病严重程度的一种可靠且安全的无创手段。