Chorami Maryam, Zojaji Homayoun, Naderi Nosratollah, Moghimi-Dehkordi Bijan, Mirsattari Dariush, Shalmani Hamid Mohaghegh
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2013 Summer;6(3):141-5.
This study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.
Helicobacter pylori infections are reported in all parts of the world. Appropriate antibiotic therapy can treat infection. The ideal treatment regimen has not been specified.
In a randomized, double blind clinical trials study, 250 patients with dyspepsia were enrolled. All patients were treated by Omeprazole, Metronidazole, Amoxicillin and Bismuth (OMAB) for two weeks. One tablet clidinium C before each meal was added to this regimen in the intervention group (A). Urea Breath Test (UBT) was carried out after 8-12 weeks after treatment for evaluation of H.pylori eradication.
132 patients in the intervention group (A) and 118 patients in the control group (B) were enrolled to the study. The rate of eradication in group A was significantly higher than group B (62.1% vs. 50%, p=0.04).
The results supported the effect of clidinium C for increasing of helicobacter pylori eradication, but further studies need to be performed.
本研究旨在通过含或不含克利溴铵C的治疗方案评估消化不良患者幽门螺杆菌根除治疗的成功率。
世界各地均有幽门螺杆菌感染的报道。适当的抗生素治疗可治愈感染。理想的治疗方案尚未明确。
在一项随机、双盲临床试验研究中，纳入了250例消化不良患者。所有患者均接受奥美拉唑、甲硝唑、阿莫西林和铋剂（OMAB）治疗两周。干预组（A组）在该治疗方案基础上，每餐饭前加服一片克利溴铵C。治疗8至12周后进行尿素呼气试验（UBT），以评估幽门螺杆菌的根除情况。
干预组（A组）有132例患者、对照组（B组）有118例患者纳入研究。A组的根除率显著高于B组（62.1%对50%，p = 0.04）。
结果支持克利溴铵C对提高幽门螺杆菌根除率的作用，但仍需进一步研究。
